Department of Pathology, Combined Military Hospital, National University of Medical Sciences (NUMS), Multan, Pakistan.
J Coll Physicians Surg Pak. 2024 May;34(5):617-619. doi: 10.29271/jcpsp.2024.05.617.
This cross-sectional study was aimed to compare insulin resistance, Triglyceride- Glucose (TyG) index, fatty liver index (FLI) and hepatic steatosis index (HSI), glycaemic and lipids among groups/quartiles based upon estimated Glucose Disposal Rate (eGDR) from August 2022 to December 2022 among 249 male participants. The eGDR results in (mg/kg/min) were divided into four quartiles as: Group-I: {<6.88, n = 62}, Group-II: {<6.88-9.45, n = 63}, Group-III: {9.46-10.39, n = 62}, and Group-IV: {>10.39, n = 62}. Fasting plasma glucose (FPG), HbA1c, low density lipoprotein (LDL), homeostasis model assessment for insulin-resistance (HOMAIR), and TyG index demonstrated significant worsening increase from high to low eGDR groups. Receiver operating curve (ROC) analysis to calculate area under curve (AUC) for diagnostic efficiency candidate indices for eGDR demonstrated highest AUC for FLI as AUC: 0.736 (95% CI: 0.669-0.803), p < 0.001, followed by FPG: AUC: 0.682 (95% CI: 0.606-0.757), HOMAIR: AUC: 0.670 (95% CI: 0.602-0.739), HSI: AUC: 0.660 (95% CI: 0.589-0.731), TyG index: 0.658 (95% CI: 0.583-0.732), and HbA1c: 0.639 (95% CI: 0.583-0.732). Glycaemic measures, lipid indices, insulin resistance and TyG index deteriorated with declining eGDR. Diagnostic performance as evaluated by AUC for eGDR was highest for FLI, followed by FPG, HOMAIR, HSI, TyG index, HbA1c, and triglycerides. Key Words: Triglyceride, Insulin, Glucose, Diabetes.
本横断面研究旨在比较胰岛素抵抗、甘油三酯-葡萄糖（TyG）指数、脂肪肝指数（FLI）和肝脂肪指数（HSI），以及根据 2022 年 8 月至 12 月 249 名男性参与者估计的葡萄糖处置率（eGDR）计算的各组/四分位数的血糖和血脂。eGDR 结果（mg/kg/min）分为四组：组 I：{<6.88，n=62}；组 II：{<6.88-9.45，n=63}；组 III：{9.46-10.39，n=62}；组 IV：>{10.39，n=62}。空腹血糖（FPG）、HbA1c、低密度脂蛋白（LDL）、胰岛素抵抗的稳态模型评估（HOMAIR）和 TyG 指数从高到低的 eGDR 组均显示出显著恶化增加。用于计算 eGDR 候选诊断效率指标的受试者工作特征曲线（ROC）分析表明，FLI 的 AUC 最高，为 0.736（95%CI：0.669-0.803），p<0.001，其次是 FPG：AUC：0.682（95%CI：0.606-0.757），HOMAIR：AUC：0.670（95%CI：0.602-0.739），HSI：AUC：0.660（95%CI：0.589-0.731），TyG 指数：0.658（95%CI：0.583-0.732），HbA1c：0.639（95%CI：0.583-0.732）。随着 eGDR 的下降，血糖测量值、血脂指数、胰岛素抵抗和 TyG 指数恶化。根据 AUC 评估的 eGDR 的诊断性能，FLI 的 AUC 最高，其次是 FPG、HOMAIR、HSI、TyG 指数、HbA1c 和甘油三酯。关键词：甘油三酯、胰岛素、葡萄糖、糖尿病。
