Department of Medicine Pt. B.D, Sharma PGIMS, Rohtak, Haryana, India.
Department of Endocrinology Pt. B.D, Sharma PGIMS, Rohtak, Haryana, India.
Diabetes Metab Syndr. 2022 Sep;16(9):102605. doi: 10.1016/j.dsx.2022.102605. Epub 2022 Aug 24.
HbAC and HOMA-IR (Homeostatic model assessment for assessing insulin resistance) are established diagnostic markers of diabetes and insulin resistance respectively, but are relatively expensive. Triglyceride glucose (TyG) index is calculated based on fasting plasma glucose and fasting triglyceride levels which are available as routine laboratory parameters and is inexpensive. This is a preliminary study which aims to compare Triglyceride glucose (TyG) index with HbAC as a marker of prediabetes and also with HOMA-IR (Homeostatic model assessment for assessing insulin resistance) as a marker of insulin resistance.
100 diagnosed cases of prediabetes and 100 age and sex-matched normoglycemic controls were recruited in the study. Fasting plasma glucose, 2-hour OGTT, fasting triglycerides, fasting plasma insulin and HbAC were measured. Triglyceride glucose (TyG) index and HOMA-IR (Homeostatic model assessment for assessing insulin resistance) were calculated. Receiver operator curve was plotted and analysed between HbAC and Triglyceride glucose (TyG) index.
Out of 100 subjects with prediabetes; 53 were female and 47 were male. In this study, there was higher mean Triglyceride glucose (TyG) index (4.942 ± 0.137 vs 4.661 ± 0.173) and HOMA-IR (Homeostatic model assessment for assessing insulin resistance) (2.424 ± 1.045 vs 1.03 ± 0.594) in individuals with prediabetes compared to normoglycemic individuals. The area under curve (AUC) for HbA1C (0.942) was more than Triglyceride glucose (TyG) index (0.898) for the diagnosis of prediabetes. But the difference was not statistically significant with p = 0.06.
Triglyceride glucose (TyG) index is comparable to HbA1C as a marker for the diagnosis of prediabetes.
HbAC 和 HOMA-IR（评估胰岛素抵抗的稳态模型评估）分别是糖尿病和胰岛素抵抗的既定诊断标志物，但相对昂贵。基于空腹血糖和空腹甘油三酯水平计算的甘油三酯葡萄糖（TyG）指数是可用作常规实验室参数的廉价指标。这是一项初步研究，旨在比较 TyG 指数作为糖尿病前期的标志物与 HbAC 的差异，以及作为胰岛素抵抗的标志物与 HOMA-IR 的差异。
本研究纳入了 100 例确诊的糖尿病前期患者和 100 例年龄和性别匹配的血糖正常对照者。测量空腹血糖、2 小时 OGTT、空腹甘油三酯、空腹胰岛素和 HbAC。计算甘油三酯葡萄糖（TyG）指数和 HOMA-IR（评估胰岛素抵抗的稳态模型评估）。绘制并分析了 HbAC 和 TyG 指数之间的接收者操作特征曲线。
在 100 例糖尿病前期患者中，53 例为女性，47 例为男性。在这项研究中，糖尿病前期患者的平均 TyG 指数（4.942±0.137 比 4.661±0.173）和 HOMA-IR（评估胰岛素抵抗的稳态模型评估）（2.424±1.045 比 1.03±0.594）均较高。HbA1C（0.942）的曲线下面积（AUC）大于 TyG 指数（0.898），用于诊断糖尿病前期。但差异无统计学意义（p=0.06）。
TyG 指数可与 HbA1C 相媲美，作为糖尿病前期的诊断标志物。
