Krishnamurthy G T, Turner F E, Mangham D, Bobba V V, White S A, Langrell K
AJR Am J Roentgenol. 1985 Apr;144(4):733-7. doi: 10.2214/ajr.144.4.733.
The intravenous dose response of a ceruletide diethylamine (ceruletide) was established by a simplified scintigraphic technique where multiple graded doses were given sequentially on a single occasion. The gallbladder volume was represented nongeometrically by 99mTc-IDA counts. The mean latent period, ejection period, and ejection rate were similar for all four groups of subjects given 1-20 ng/kg of ceruletide. The mean (+/- SD) ejection fractions after 1, 5, 10, and 15 ng/kg of ceruletide as the single dose were 19.4 +/- 11.9%, 59.6 +/- 26.0%, 55.2 +/- 23.3%, and 67.8 +/- 8.7%, respectively. These ejection fractions were similar to the values when the identical dose of ceruletide was administered sequentially either before or after another dose. A dose of 5 ng/kg produced the most physiologic type of emptying. Intravenous doses of 10 ng/kg and larger caused adverse reactions in 42% of the total doses in the form of abdominal pain, nausea, systolic and diastolic hypotension, or bradycardia. It is concluded that the dose response of a cholecystokininlike agent (ceruletide) can be established reliably by a scintigraphic technique where multiple graded doses are given on a single occasion.
采用一种简化的闪烁扫描技术确定了蛙皮素二乙胺（蛙皮素）的静脉给药剂量反应，该技术在单次给药时依次给予多个分级剂量。胆囊体积以99mTc - IDA计数非几何地表示。给予1 - 20 ng/kg蛙皮素的所有四组受试者的平均潜伏期、射血期和射血率相似。单次给予1、5、10和15 ng/kg蛙皮素后的平均（±标准差）射血分数分别为19.4±11.9%、59.6±26.0%、55.2±23.3%和67.8±8.7%。这些射血分数与在另一剂量之前或之后依次给予相同剂量蛙皮素时的值相似。5 ng/kg的剂量产生了最接近生理状态的排空类型。静脉注射10 ng/kg及更大剂量时，42%的总剂量出现不良反应，表现为腹痛、恶心、收缩压和舒张压降低或心动过缓。结论是，通过在单次给药时给予多个分级剂量的闪烁扫描技术，可以可靠地确定一种胆囊收缩素样药物（蛙皮素）的剂量反应。
