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氟虫腈（Exzolt）对家鸡（Gallus gallus domesticus）防治三锥虫（半翅目，锥蝽科，锥蝽亚科）的杀虫活性。

Insecticidal activity of fluralaner (Exzolt) administered to Gallus gallus domesticus against triatomines (Hemiptera, Reduviidae, Triatominae).

机构信息

Graduate Program in Parasitary Biology, Federal University of Rio Grande do Norte, Natal, Brazil.

Graduate Program in Biological and Health Sciences, Federal University of Vale do São Francisco, Petrolina, Brazil.

出版信息

Parasit Vectors. 2024 May 8;17(1):208. doi: 10.1186/s13071-024-06276-8.

DOI:10.1186/s13071-024-06276-8
PMID:38720313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11080163/
Abstract

BACKGROUND

Triatoma infestans, Triatoma brasiliensis, Triatoma pseudomaculata and Rhodnius prolixus are vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Chickens serve as an important blood food source for triatomines. This study aimed to assess the insecticidal activity of fluralaner (Exzolt) administered to chickens against triatomines (R. prolixus, T. infestans, T. brasiliensis and T. pseudomaculata).

METHODS

Twelve non-breed chickens (Gallus gallus domesticus) were randomized based on weight into three groups: negative control (n = 4); a single dose of 0.5 mg/kg fluralaner (Exzolt) (n = 4); two doses of 0.5 mg/kg fluralaner (Exzolt) (n = 4). Nymphs of 3rd, 4th and 5th instars of R. prolixus, T. infestans, T. brasiliensis and T. pseudomaculata (all n = 10) were allowed to feed on chickens before treatment, and at intervals of 1, 7, 14, 21, 28, 35 and 56 days after treatment, with insect mortality determined.

RESULTS

Treatment with two doses of fluralaner showed higher insecticidal efficacy against R. prolixus, T. infestans and T. brasiliensis compared to the single-dose treatment. Similar insecticidal efficacy was observed for T. pseudomaculata for one and two doses of fluralaner. Insecticidal activity of fluralaner (Exzolt) against triatomine bugs was noted up to 21 and 28 days after treatment with one and two doses of fluralaner, respectively.

CONCLUSIONS

The results demonstrate that treatment of chickens with fluralaner (Exzolt) induces insecticidal activity against triatomines for up to 28 days post-treatment, suggesting its potential use as a control strategy for Chagas disease in endemic areas.

摘要

背景

传播恰加斯病（又称美洲锥虫病）的病原体克氏锥虫的主要媒介是三带喙库蚊、巴西游走蛛、长红猎蝽和普氏锥蝽。鸡是这些三锥虫的重要血食源。本研究旨在评估氟虫腈（Exzolt）对鸡的杀虫活性，以对抗三锥虫（R. prolixus、T. infestans、T. brasiliensis 和 T. pseudomaculata）。

方法

根据体重，将 12 只非繁殖鸡（Gallus gallus domesticus）随机分为三组：阴性对照组（n=4）；单次剂量 0.5mg/kg 氟虫腈（Exzolt）（n=4）；两次剂量 0.5mg/kg 氟虫腈（Exzolt）（n=4）。三龄、四龄和五龄的 R. prolixus、T. infestans、T. brasiliensis 和 T. pseudomaculata 若虫（每组 n=10）在治疗前被允许在鸡身上取食，然后在治疗后 1、7、14、21、28、35 和 56 天间隔时，测定昆虫死亡率。

结果

与单次剂量处理相比，两次剂量处理对 R. prolixus、T. infestans 和 T. brasiliensis 的杀虫效果更高。单次和两次剂量的氟虫腈对 T. pseudomaculata 也表现出相似的杀虫效果。单次和两次剂量的氟虫腈对三带喙库蚊的杀虫活性分别在治疗后 21 天和 28 天观察到。

结论

结果表明，用氟虫腈（Exzolt）处理鸡可诱导三锥虫的杀虫活性，最长可持续 28 天，提示其在流行地区作为恰加斯病控制策略的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/1ff61a36b78b/13071_2024_6276_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/e9eec8e55c8e/13071_2024_6276_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/4d0ca3a01952/13071_2024_6276_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/d84fd0bfbf99/13071_2024_6276_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/5cb9caa56658/13071_2024_6276_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/1ff61a36b78b/13071_2024_6276_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/e9eec8e55c8e/13071_2024_6276_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/4d0ca3a01952/13071_2024_6276_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/d84fd0bfbf99/13071_2024_6276_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/5cb9caa56658/13071_2024_6276_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c70/11080163/1ff61a36b78b/13071_2024_6276_Fig5_HTML.jpg

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Am J Trop Med Hyg. 2023 Sep 25;109(5):1012-1021. doi: 10.4269/ajtmh.23-0300. Print 2023 Nov 1.
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Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius, in poultry facilities.氟虫腈作为一种全身用药物控制家禽设施中常见的臭虫（Cimex lectularius）侵扰的药代动力学。
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Parasit Vectors. 2023 Jun 2;16(1):178. doi: 10.1186/s13071-023-05805-1.
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Enzootic infection by shows transmission to humans and dogs in Vichada, Colombia.在哥伦比亚维查达，地方性感染的 导致人类和狗感染。
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