Resident Doctor, Department of General Medicine, SMS Medical College, Jaipur, Rajasthan, India, Corresponding Author.
Senior Professor, Department of General Medicine, SMS Medical College, Jaipur, Rajasthan, India.
J Assoc Physicians India. 2023 Nov;71(11):40-42. doi: 10.59556/japi.71.0375.
: Systemic lupus erythematosus (SLE) is an autoimmune disease which is characterized by chronic multisystem inflammation and end-organ damage. In recent times there has been a need for new hematological markers to assess disease activity in SLE patients specifically, which can be easily available like eosinophil, basophil, neutrophil, monocytes, and platelet to lymphocyte ratios (ELR, BLR, NLR, MLR, and PLR, respectively). : The present investigation determines the use of a different peripheral hematological marker to assess SLE activity in 106 patients attended for medical care at Sawai Mansingh (SMS) Medical College and attached hospital, Jaipur. SLE disease activity index 2000 (SLEDAI-2K) was used to assess the disease activity in all patients. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were assessed in each subject. The ratio of various hematological indices, like NLR, BLR, ELR, MLR, PLR, etc., analyzed and correlated with CRP, ESR, and SLEDAI-2K. : The present study revealed that the SLEDAI-2K score showed a significant positive correlation with ELR and MLR ( < 0.005). CRP showed a significant positive correlation with PLR ( < 0.005). ESR showed a significant positive correlation with ELR, MLR, PLR, and NLR ( < 0.005). : The final results demonstrate that in SLE patients, the ratio of hematological indices like ELR, MLR, and PLR can be employed as disease activity markers. : Meena VP, Meena PD, Chejara RS, Analysis of Hematological Indices in Patients of Systemic Lupus Erythematous and Its Correlation with SLEDAI-2K. J Assoc Physicians India 2023;71(11):40-42.
: 系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征为慢性多系统炎症和靶器官损伤。最近，人们需要新的血液学标志物来专门评估 SLE 患者的疾病活动度，这些标志物应该像嗜酸性粒细胞、嗜碱性粒细胞、中性粒细胞、单核细胞和血小板与淋巴细胞比值（ELR、BLR、NLR、MLR 和 PLR）一样易于获得。 : 本研究旨在确定使用不同的外周血学标志物来评估 106 例在斋浦尔的萨瓦伊·曼辛格（SMS）医学院和附属医院接受治疗的 SLE 患者的疾病活动度。所有患者均采用 2000 年系统性红斑狼疮疾病活动指数（SLEDAI-2K）评估疾病活动度。对每位患者进行红细胞沉降率（ESR）和 C 反应蛋白（CRP）评估。分析并比较各种血液学指标的比值，如 NLR、BLR、ELR、MLR、PLR 等，与 CRP、ESR 和 SLEDAI-2K 相关。 : 本研究显示，SLEDAI-2K 评分与 ELR 和 MLR 呈显著正相关（<0.005）。CRP 与 PLR 呈显著正相关（<0.005）。ESR 与 ELR、MLR、PLR 和 NLR 呈显著正相关（<0.005）。 : 最终结果表明，在 SLE 患者中，ELR、MLR 和 PLR 等血液学指标的比值可作为疾病活动的标志物。 : Meena VP, Meena PD, Chejara RS, 分析系统性红斑狼疮患者的血液学指标及其与 SLEDAI-2K 的相关性。印度医师协会杂志 2023 年；71（11）：40-42。
