Division of Pediatric Gastroenterology, Hospital Jaraguá, Jaraguá do Sul, Brazil.
Universidade Municipal de São Caetano do Sul, São Caetano do Sul, Brazil.
J Pediatr Gastroenterol Nutr. 2024 Oct;79(4):855-862. doi: 10.1002/jpn3.12231. Epub 2024 May 8.
Infantile colic is excessive crying for no apparent reason in an otherwise healthy infant. Although its physiopathology is not completely understood, therapies usually target gastrointestinal symptoms. This systematic review of randomized controlled trials (RCTs) analyzes the efficacy of lactase supplementation in infantile colic. PubMed, Embase, and Cochrane were searched for RCTs evaluating lactase supplementation in infants up to 6 months old with infantile colic. Out of six RCTs including 394 patients, three reported a significantly shorter crying time in the lactase group than in the placebo group, while the other three found no significant difference between groups. Of the two studies that performed the hydrogen breath test, only one reported a significant reduction in exhaled hydrogen levels. The pharmacological approach to infantile colic remains debatable, and new studies with standardized diagnostic criteria and outcomes are required to guide lactase supplementation in clinical practice.
婴儿肠绞痛是指健康婴儿无明显原因的过度哭闹。尽管其病理生理学尚未完全阐明，但治疗方法通常针对胃肠道症状。本系统评价对随机对照试验（RCT）进行分析，评估乳糖酶补充剂对婴儿肠绞痛的疗效。对评估婴儿肠绞痛的乳糖酶补充剂的 RCT 进行了 PubMed、Embase 和 Cochrane 检索，纳入的婴儿年龄为 6 个月以下。在纳入的 6 项 RCT 中，共 394 例患儿，其中 3 项研究表明乳糖酶组的哭闹时间显著短于安慰剂组，而另外 3 项研究则未发现组间差异。在进行氢呼气试验的两项研究中，仅有一项报道呼气氢水平显著降低。对于婴儿肠绞痛的药物治疗方法仍存在争议，需要新的研究采用标准化的诊断标准和结局来指导临床实践中乳糖酶的补充。
