Ahmed Mubashir, Billoo Abdul Gaffar, Iqbal Khalid, Memon Ashraf
Kharadar General Hospital, Karachi.
Kharadar General Hospital, Karachi .
J Pak Med Assoc. 2018 Dec;68(12):1744-1747.
To determine the efficacy of lactase enzyme supplement in infant colic.
The double-blind randomised clinical trial was conducted from November 2014 to June 2017 at Kharadar General Hospital, Karachi, and comprised infants aged 0-6 months with infant colic, excessive crying lasting at least 3 hours a day on at least 3 days a week for at least 3 weeks. The subjects were randomised into intervention group A which received lactase enzyme Colibid, and placebo group B. Five drops of intervention preparation were received by all the infants before each feed for two weeks. Confidentiality of active agent and placebo was maintained through drug codes. The duration of crying was recorded at baseline then after first and second weeks of intervention. The two groups were compared with level of significance set at p<0.05.
There were 104 subjects with 52(50%) in each of the two groups Overall, 50(48.1%) were boys. At baseline, all (100%) the subjects had infant colic or excessive crying. After two-week intervention, significant improvement was seen in the duration of crying in group A 45(86.5%) compared to group B 31(59.6%) (p<0.05).
Significant improvement was seen in the duration of crying in infants who received lactase enzyme supplement..
确定乳糖酶补充剂对婴儿腹绞痛的疗效。
2014年11月至2017年6月在卡拉奇的哈拉达尔综合医院进行了双盲随机临床试验，纳入年龄在0至6个月、患有婴儿腹绞痛、每周至少3天每天哭闹至少3小时且持续至少3周的婴儿。将受试者随机分为接受乳糖酶制剂科利比德的干预组A和安慰剂组B。所有婴儿在每次喂奶前接受5滴干预制剂，持续两周。通过药物编码保持活性剂和安慰剂的保密性。在基线时以及干预的第一周和第二第二二两周后记录哭闹持续时间。两组进行比较，显著性水平设定为p<0.05。
共有104名受试者，两组各52名（50%）。总体而言，50名（48.1%）为男孩。在基线时所有（100%）受试者均有婴儿腹绞痛或哭闹过度。经过两周干预后，A组哭闹持续时间有显著改善的有45名（86.5%），而B组为31名（59.6%）（p<0.05）。
接受乳糖酶补充剂的婴儿哭闹持续时间有显著改善。
