Eitches R W, Rachelefsky G S, Katz R M, Mendoza G R, Siegel S C
Am J Dis Child. 1985 Mar;139(3):264-8. doi: 10.1001/archpedi.1985.02140050058022.
Oral methylprednisolone combined with troleandomycin has been reported to be successful in treating poorly controlled, severe asthma in adults. We found this drug combination to be effective in treating 11 steroid-dependent children with poorly controlled asthma who were aged 7 to 13 years, for 12 to 28 months. Improvement of clinical and pulmonary functions was achieved within seven days, with the forced expiratory volume in 1 s increasing by 38% and the maximal midexpiratory flow rate increasing by 55% over the baseline value. By one year, the former improved to 98% of predicted value and the latter, to 79% of predicted value. Compared with the prior 12 months, patients at this time required fewer emergency visits, missed fewer days of school, and had fewer hospitalizations. Side effects included transient-increased cushingoid features, abdominal pain, and liver enzyme level elevation. Patients showed less evidence of adrenal suppression.
据报道，口服甲基强的松龙联合醋竹桃霉素成功治疗了成人控制不佳的重度哮喘。我们发现这种药物组合对11名7至13岁、哮喘控制不佳的类固醇依赖儿童有效，治疗时间为12至28个月。临床和肺功能在7天内得到改善，1秒用力呼气量较基线值增加了38%，最大呼气中期流速增加了55%。到1年时，前者改善到预测值的98%，后者改善到预测值的79%。与之前的12个月相比，此时患者的急诊就诊次数减少，缺课天数减少，住院次数减少。副作用包括短暂性库欣样特征增加、腹痛和肝酶水平升高。患者肾上腺抑制的证据较少。
