Schwartz M, Creasey H, Grady C L, DeLeo J M, Frederickson H A, Cutler N R, Rapoport S I
Ann Neurol. 1985 Feb;17(2):146-57. doi: 10.1002/ana.410170208.
Computed transverse axial tomography (CT) was employed to examine brain morphometrics in 30 healthy men, aged 21 to 81 years. Seven consecutive CT slices 30 to 80 mm above the inferior orbitomeatal line were analyzed. CT numbers in gray and white matter regions were not correlated significantly with age (p greater than 0.05), nor were right/left ratios for derived parameters. The volume of gray matter was correlated negatively with age (p less than 0.05), and the volume of cerebrospinal fluid correlated positively with age, in the seven slices. The volumes of the lateral and third ventricles were elevated in the elderly, and volumes of the thalamus and lenticular nucleus were reduced. The results demonstrate that brain atrophy, evidenced by a loss of gray matter and by dilatation of cerebrospinal fluid spaces, occurs in the healthy elderly, and provide baseline CT-derived brain morphometric data for healthy men in relation to age.
采用计算机断层轴向扫描（CT）对30名年龄在21至81岁之间的健康男性的脑形态计量学进行检查。分析了眶耳线下方30至80毫米处连续的7层CT切片。灰质和白质区域的CT数值与年龄无显著相关性（p大于0.05），推导参数的左右比值也无显著相关性。在这7层切片中，灰质体积与年龄呈负相关（p小于0.05），脑脊液体积与年龄呈正相关。老年人的侧脑室和第三脑室体积增大，丘脑和豆状核体积减小。结果表明，健康老年人会出现脑萎缩，表现为灰质减少和脑脊液间隙扩张，并提供了基于CT的健康男性脑形态计量学与年龄相关的基线数据。
