Hershey L A, Gado M H, Trotter J L
Ann Neurol. 1979 Jan;5(1):32-9. doi: 10.1002/ana.410050106.
Sixty-six patients with a tentative or certain diagnosis of multiple sclerosis (MS) were examined with cranial computerized tomography (CT). Abnormalities found in 19 (29%) included discrete areas of decreased white matter density, enlarged ventricles, cortical atrophy, and focal areas of contrast enhancement. The presence of white matter lucencies and ventricular dilatation correlated with an increased incidence of diffuse hyperreflexia and mental impairment. Since half the patients with contrast-enhancing lesions were clinically stable, their lesions may represent acute asymptomatic plaques. Abnormalities on CT scan were observed more often in older patients whose disease had lasted longer and was clinically more definite. Since findings were sparse in early, less definite disease, the use of CT as a purely diagnostic tool is limited.
66例初步诊断或确诊为多发性硬化症（MS）的患者接受了头颅计算机断层扫描（CT）检查。在19例（29%）患者中发现的异常包括白质密度降低的离散区域、脑室扩大、皮质萎缩以及对比增强的局灶性区域。白质透亮区和脑室扩张的存在与弥漫性反射亢进和精神障碍的发生率增加相关。由于有对比增强病变的患者中有一半临床症状稳定，他们的病变可能代表急性无症状斑块。CT扫描异常在病程较长且临床诊断更明确的老年患者中更常见。由于在早期、诊断不明确的疾病中发现较少，CT作为一种单纯的诊断工具的用途有限。
