Levine A M, Burkes R L, Walker M, Meyer P R, Gill P S, Nichols P W, Dworsky R, Parker J W, Lukes R J
Arch Intern Med. 1985 Mar;145(3):479-81.
Opportunistic infections and malignant neoplasms have been described in homosexual men in association with immunologic abnormalities. We observed the development of malignant B-cell lymphomas in two homosexual men who had had a monogamous relationship for two years. Patient 1 had an aggressive, monoclonal, small, noncleaved, non-Burkitt's lymphoma ("undifferentiated lymphoma"), associated with severe immunocompromise. Patient 2 manifested a monoclonal, small, cleaved, follicular center cell lymphoma, with a follicular pattern, two months later. No common acute infection was detected. Staining for Epstein-Barr nuclear antigen in malignant tissue was negative in the second patient. However, the possibility of a transmissible agent as a causative factor cannot be excluded, and further study of similar patients is warranted.
机会性感染和恶性肿瘤已在同性恋男性中被描述为与免疫异常有关。我们观察到两名处于一夫一妻制关系两年的同性恋男性发生了恶性B细胞淋巴瘤。患者1患有侵袭性、单克隆、小型、无裂、非伯基特淋巴瘤（“未分化淋巴瘤”），伴有严重免疫功能低下。两个月后，患者2表现出单克隆、小型、有裂、滤泡中心细胞淋巴瘤，呈滤泡型。未检测到常见的急性感染。在第二名患者的恶性组织中，爱泼斯坦-巴尔核抗原染色为阴性。然而，不能排除可传播因子作为致病因素的可能性，因此有必要对类似患者进行进一步研究。
