Allergy Center, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
ENT Department, University of Molise, Campobasso, Italy.
Allergol Immunopathol (Madr). 2024 May 1;52(3):22-30. doi: 10.15586/aei.v52i3.1040. eCollection 2024.
Preschoolers frequently have respiratory infections (RIs), which may cause wheezing in some subjects. Type 2 polarization may favor increased susceptibility to RIs and associated wheezing. Non-pharmacological remedies are garnering increasing interest as possible add-on therapies. The present preliminary study investigated the efficacy and safety of a new multi-component nasal spray in preschoolers with frequent RIs and associated wheezing.
Some preschoolers with these characteristics randomly took this product, containing lactoferrin, dipotassium glycyrrhizinate, carboxymethyl-beta-glucan, and vitamins C and D3 (Saflovir), two sprays per nostril twice daily for 3 months. Other children were randomly treated only with standard therapy. Outcomes included the number of RIs and wheezing episodes, use of medications, and severity of clinical manifestations.
Preschoolers treated add-on with this multicomponent product experienced fewer RIs and used fewer beta-2 agonists than untreated children (P = 0.01 and 0.029, respectively).
This preliminary study demonstrated that a multicomponent product, administered add-on as a nasal spray, could reduce the incidence of RIs and use of symptomatic drugs for relieving wheezing in children.
学龄前儿童经常患有呼吸道感染（RIs），其中一些患者可能会出现喘息。2 型极化可能使呼吸道感染和相关喘息的易感性增加。非药物治疗作为可能的附加治疗方法越来越受到关注。本初步研究调查了一种新的多成分鼻喷雾剂在频繁发生呼吸道感染和相关喘息的学龄前儿童中的疗效和安全性。
一些具有这些特征的学龄前儿童随机使用含有乳铁蛋白、甘草酸二钾、羧甲基-β-葡聚糖、维生素 C 和 D3（Saflovir）的产品，每天每侧鼻孔喷两次，持续 3 个月。其他儿童随机仅接受标准治疗。结果包括呼吸道感染和喘息发作的次数、药物使用情况以及临床表现的严重程度。
接受这种多成分产品辅助治疗的学龄前儿童呼吸道感染和使用β-2 激动剂的次数比未治疗的儿童少（P = 0.01 和 0.029）。
这项初步研究表明，作为鼻喷雾剂辅助给药的多成分产品可降低儿童呼吸道感染的发生率，并减少缓解喘息症状的药物使用。
