Department of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Department of Public Health, Southern Medical University, No.1023, ShaTai South Road, Guangzhou City, Guangdong Province, 510515, China.
Future Oncol. 2024;20(18):1275-1287. doi: 10.2217/fon-2023-0922. Epub 2024 May 9.
This study aimed to systematically evaluate the value of miRNA-143 in the early detection of bladder cancer (BCa). CNKI, WanFang, PubMed and Wiley Online Library databases were explored according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. A random-effects model was used to obtain pooled sensitivity, specificity and other related indicates. Six studies were included for analysis. The overall pooled sensitivity and specificity were 0.80 (95% CI: 0.74-0.85) and 0.85 (95% CI: 0.78-0.91), and the area under the curve was 0.88 (95% CI: 0.85-0.91). Coupled with miR-100, it showed better diagnostic power (area under the curve: 0.95). miRNA-143 may serve as a promising noninvasive tool for the early detection of BCa.
本研究旨在系统评估 miRNA-143 在膀胱癌（BCa）早期检测中的价值。根据系统评价和荟萃分析的首选报告项目，检索了中国知网、万方、PubMed 和 Wiley Online Library 数据库。使用随机效应模型获得了汇总的敏感性、特异性和其他相关指标。纳入了 6 项研究进行分析。总的汇总敏感性和特异性分别为 0.80（95%置信区间：0.74-0.85）和 0.85（95%置信区间：0.78-0.91），曲线下面积为 0.88（95%置信区间：0.85-0.91）。与 miR-100 联合使用，显示出更好的诊断效能（曲线下面积：0.95）。miRNA-143 可能成为一种有前途的膀胱癌早期检测的非侵入性工具。
