急性淋巴细胞的超微结构分析：花生凝集素结合与白血病细胞的分化程度相关。
Ultrastructural analysis of acute lymphoblastic cells: peanut lectin binding correlates with degree of differentiation of the leukemic cells.
作者信息
Haar J L, Raynor R H, Russell E C, Bhatnagar A S, Mohanakumar T
出版信息
Exp Hematol. 1985 Mar;13(3):169-73.
Peanut agglutinin (PNA) has been shown to bind selectively to immature cells. Bone marrow cells from some children having acute lymphocytic leukemia (ALL) bind PNA while cells from other ALL patients do not bind, the significance being that the patients whose cells bind PNA have a poorer prognosis than those not binding PNA. In the present study, PNA was conjugated to horseradish peroxidase and the two cell types were compared. Cells binding PNA are immature compared with the non-PNA-binding cells.
花生凝集素（PNA）已被证明能选择性地与未成熟细胞结合。一些患有急性淋巴细胞白血病（ALL）的儿童的骨髓细胞能结合PNA，而其他ALL患者的细胞则不结合，其意义在于细胞能结合PNA的患者预后比不结合PNA的患者更差。在本研究中，将PNA与辣根过氧化物酶偶联，并对这两种细胞类型进行了比较。与不结合PNA的细胞相比，结合PNA的细胞是未成熟的。
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