Von Hoff D D, Schilsky R, Reichert C M, Reddick R L, Rozencweig M, Young R C, Muggia F M
Cancer Treat Rep. 1979 Sep-Oct;63(9-10):1527-31.
Administration of cis-dichlorodiammineplatinum(II) may be associated with a number of serious side effects, including nephrotoxicity, gastroeintestinal side effects (nausea, vomiting, and diarrhea), myelosuppression, and occasional transient elevations in liver function tests. In addition, ototoxicity (tinnitus and hearing loss), anaphylactic reactions, peripheral neuropathies, and hypomagnesemia with resulting tetany may also be encountered. The toxic potential of this new agent necessitates careful clinical monitoring during treatment.
顺二氯二氨铂（II）的给药可能会伴有一些严重的副作用，包括肾毒性、胃肠道副作用（恶心、呕吐和腹泻）、骨髓抑制以及偶尔出现的肝功能检查短暂升高。此外，还可能会出现耳毒性（耳鸣和听力丧失）、过敏反应、周围神经病变以及导致手足搐搦的低镁血症。这种新药的潜在毒性使得在治疗期间需要进行仔细的临床监测。
