Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.
Heart Fail Rev. 2024 Jul;29(4):811-826. doi: 10.1007/s10741-024-10399-6. Epub 2024 May 9.
Obstructive sleep apnea (OSA) is a disease with intermittent hypoxemia during sleep. It has been shown that OSA is related to several cardiovascular diseases including heart failure. Both OSA and heart failure have a close association bidirectionally. This study aimed to estimate the pooled prevalence of OSA in patients with heart failure as well as pooled prevalence of heart failure in patients with OSA. This was a systematic review with a meta-analysis. The inclusion criteria were observational or epidemiological studies conducted in adult patients with heart failure to evaluate the prevalence of OSA and patients with OSA to evaluate the prevalence of heart failure. The outcomes of this study were prevalence of OSA in patients with heart failure and prevalence of heart failure in patients with OSA. Four databases were used for systematic searching including PubMed, Science Direct, Scopus, and CINAHL Plus. Manual searches for related studies were also conducted. Proportion meta-analyses using a random-effects model were conducted to identify pooled proportion (prevalence) of heart failure in patients with OSA and vice versa. Among 3,941 articles from the four databases met the study criteria. Thirty-three studies showed the prevalence of OSA in patients with heart failure, while thirteen studies presented the prevalence of heart failure in patients with OSA. The prevalence of OSA in patients with heart failure was 38.4% (95% CI 31.9 to 45.2; I of 96.1%). Using a diagnostic criterion of OSA of more than 10 events/hr had the highest prevalence of OSA in patients with heart failure at 53.4% (95% CI 42.0 to 64.5). The highest prevalence of OSA in patients with heart failure was 60.1% (95% CI 51.4 to 68.3) in a report from India. The pooled prevalence of heart failure in patients with OSA was 12.8% (95% CI 8.1 to 19.5; I of 94.6%). The prevalence in Romania was highest at 22.6% (95% CI 20.4 to 24.9). The pooled prevalence of OSA in patients with heart failure was higher than the pooled prevalence of heart failure in patients with OSA. The pooled prevalence rates of these associations varied among the diagnostic criteria of OSA and countries.
阻塞性睡眠呼吸暂停（OSA）是一种在睡眠期间间歇性缺氧的疾病。有研究表明，OSA 与多种心血管疾病有关，包括心力衰竭。OSA 和心力衰竭之间存在着密切的双向关联。本研究旨在评估心力衰竭患者中 OSA 的总患病率，以及 OSA 患者中心力衰竭的总患病率。这是一项系统综述和荟萃分析。纳入标准是对心力衰竭成年患者进行的观察性或流行病学研究，以评估 OSA 的患病率，以及对 OSA 患者进行评估心力衰竭的患病率。本研究的结局是心力衰竭患者中 OSA 的患病率和 OSA 患者中心力衰竭的患病率。系统检索了 4 个数据库，包括 PubMed、Science Direct、Scopus 和 CINAHL Plus，并进行了相关研究的手工检索。使用随机效应模型进行比例荟萃分析，以确定 OSA 患者中心力衰竭的总患病率（患病率）和相反的情况。从 4 个数据库中检索到的 3941 篇文章符合研究标准。33 项研究显示了心力衰竭患者中 OSA 的患病率，而 13 项研究显示了 OSA 患者中心力衰竭的患病率。心力衰竭患者中 OSA 的患病率为 38.4%（95%CI 31.9 至 45.2；I 为 96.1%）。使用 OSA 诊断标准超过 10 次/小时的事件，心力衰竭患者中 OSA 的患病率最高，为 53.4%（95%CI 42.0 至 64.5）。来自印度的一份报告显示，心力衰竭患者中 OSA 的患病率最高为 60.1%（95%CI 51.4 至 68.3）。OSA 患者中心力衰竭的总患病率为 12.8%（95%CI 8.1 至 19.5；I 为 94.6%）。罗马尼亚的患病率最高，为 22.6%（95%CI 20.4 至 24.9）。心力衰竭患者中 OSA 的总患病率高于 OSA 患者中心力衰竭的总患病率。这些关联的汇总患病率因 OSA 的诊断标准和国家而异而有所不同。
