de Catanzaro D, Lee P C, Kerr T H
Horm Behav. 1985 Mar;19(1):77-85. doi: 10.1016/0018-506x(85)90008-x.
Ovariectomized mice were given replacement estrogen and progesterone, and tested for sexual receptivity in the presence of mounting males after various pharmacological manipulations of adrenocortical hormone activity. In Experiment I, females received a chronic regimen of varied dosages of metyrapone, which blocks adrenal conversion of desoxycorticosterone to corticosterone. In each of three repeated measures, females given an intermediate dosage (800 micrograms/animal/injection) showed substantially higher levels of receptivity than those given vehicle injections or other dosages. In Experiment 2, corticosterone administration reversed the facilitatory action of metyrapone on receptivity. In Experiment 3, chronic administration of either desoxycorticosterone or progesterone failed to elevate receptivity. These findings suggest that corticosterone titer may play a role in modulating female receptivity in sexually inexperienced mice.
对卵巢切除的小鼠给予雌激素和孕酮替代治疗，并在对肾上腺皮质激素活性进行各种药理学操作后，在有爬跨行为的雄性小鼠存在的情况下测试其性接受能力。在实验I中，雌性小鼠接受不同剂量美替拉酮的长期给药方案，美替拉酮可阻断脱氧皮质酮向皮质酮的肾上腺转化。在三次重复测量的每一次中，给予中等剂量（800微克/动物/注射）的雌性小鼠的接受能力水平显著高于给予溶剂注射或其他剂量的雌性小鼠。在实验2中，给予皮质酮可逆转美替拉酮对接受能力的促进作用。在实验3中，长期给予脱氧皮质酮或孕酮均未能提高接受能力。这些发现表明，皮质酮水平可能在调节性经验不足的小鼠的雌性接受能力方面发挥作用。
