Sidhu G S, Stahl R E, el-Sadr W, Cassai N D, Forrester E M, Zolla-Pazner S
Hum Pathol. 1985 Apr;16(4):377-86. doi: 10.1016/s0046-8177(85)80231-8.
Blood and a variety of tissues from 97 patients with the acquired immunodeficiency syndrome (AIDS) and 25 with the AIDS prodrome were studied ultrastructurally. Tubuloreticular structures (TRS) were found in 85 per cent of the patients with AIDS and in 92 per cent of those with the prodrome. Test tube and ring-shaped forms (TRF), found in 41 per cent of the patients with AIDS and in 8 per cent of those with the prodrome, increased with disease progression. Among the patients with AIDS, as the number of sites examined per case increased, the incidence of TRS and TRF tended to approach 100 per cent, suggesting that they are present in all patients with AIDS. Other changes seen frequently were immunologic capping of blood lymphocytes, intramitochondrial iron in blood reticulocytes and marrow normoblasts, megakaryocytic immaturity and platelet phagocytosis, collections of membranous rings in hepatocytic cytoplasm, suggestive of non-A, non-B hepatitis, and proliferations and engorgement of hepatic Ito cells with lipid. The data suggest that TRS and TRF can be used as diagnostic and prognostic markers.
对97例获得性免疫缺陷综合征（艾滋病）患者和25例艾滋病前驱期患者的血液及多种组织进行了超微结构研究。在85%的艾滋病患者和92%的前驱期患者中发现了管状网状结构（TRS）。试管状和环状形式（TRF）在41%的艾滋病患者和8%的前驱期患者中被发现，并随着疾病进展而增加。在艾滋病患者中，随着每个病例检查部位数量的增加，TRS和TRF的发生率趋于接近100%，表明它们存在于所有艾滋病患者中。常见的其他变化包括血液淋巴细胞的免疫盖帽、血液网织红细胞和骨髓幼红细胞线粒体内的铁、巨核细胞不成熟和血小板吞噬、肝细胞质中膜环的聚集（提示非甲非乙型肝炎）以及肝贮脂细胞的增殖和脂质充盈。数据表明，TRS和TRF可作为诊断和预后标志物。
