Saito S
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Mar;37(3):391-400.
There are many reports on the immune complexes in normal pregnancies. Nevertheless, even the presence of immune complexes in normal pregnancies have not been clarified, and the immune complexes have not been clearly characterized. So, in this report, I try to make clear whether immune complexes are present in normal pregnancies or not, and then to analyze the immune complexes in normal pregnancies. The results are as follows: The immune complex (IC) levels measured by the C1q binding test rose in first trimester, and dropped to the normal range in the second and third trimesters. The IgG-IC levels increased in the first trimester and decreased to the normal range in the second and third trimesters, but the IgM-IC levels were not changed during normal pregnancies in the solid phase anti C3 radioimmunoassay. The ICs in normal pregnancies were analyzed using gel filtration. IgG-ICs were detected in the first trimester and the third trimester of normal pregnancies, and the molecular weights were about 290,000. IgG-ICs were separated from another immunoglobulin class IC using a DEAE-affigel blue column. ICs in normal pregnancies were mainly IgG-IC and there were only a few IgM-ICs in normal pregnancies. IgG-ICs were present in normal pregnancies, but neither the classical pathway nor the alternative pathway of the complement system was found to be activated by the two-dimensional electroimmunodiffusion method using anti C3 and C1s. So, IgG-IC in normal pregnancies did not seem to be pathological.
关于正常妊娠中免疫复合物的报道众多。然而，即便正常妊娠中存在免疫复合物这一点也尚未明确，且免疫复合物的特征也未被清晰界定。因此，在本报告中，我试图明确正常妊娠中是否存在免疫复合物，进而分析正常妊娠中的免疫复合物。结果如下：通过C1q结合试验测得的免疫复合物（IC）水平在妊娠早期升高，在妊娠中期和晚期降至正常范围。在固相抗C3放射免疫分析中，IgG - IC水平在妊娠早期升高，在妊娠中期和晚期降至正常范围，但IgM - IC水平在正常妊娠期间无变化。利用凝胶过滤法对正常妊娠中的IC进行分析。在正常妊娠的早期和晚期检测到IgG - IC，其分子量约为290,000。使用DEAE - 琼脂糖蓝柱将IgG - IC与其他免疫球蛋白类IC分离。正常妊娠中的IC主要为IgG - IC，正常妊娠中仅有少量IgM - IC。正常妊娠中存在IgG - IC，但采用抗C3和C1s的二维电免疫扩散法未发现补体系统的经典途径或替代途径被激活。所以，正常妊娠中的IgG - IC似乎并非病理性的。
