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一篇关于“经导管主动脉瓣植入术(TAVI)局部麻醉与全身麻醉:随机和倾向评分匹配研究的系统评价、荟萃分析和试验序贯分析”文章的述评。

A review regarding the article 'Local versus General Anaesthesia for Transcatheter Aortic Valve Implantation (TAVI): A systematic review, meta-analysis, and trial sequential analysis of randomised and propensity-score matched studies'.

机构信息

Department of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan, Chengdu 610072, China.

Department of Anesthesiology, Chengdu Seventh People's Hospital, Sichuan, Chengdu 610072, China.

出版信息

Curr Probl Cardiol. 2024 Jul;49(7):102629. doi: 10.1016/j.cpcardiol.2024.102629. Epub 2024 May 7.

DOI:10.1016/j.cpcardiol.2024.102629
PMID:38723797
Abstract

Transcatheter aortic valve implantation (TAVI) is a promising treatment strategy for high-risk surgical patients, and trials investigating its effectiveness in intermediate- and lower-risk patients are underway. Data are inconsistent regarding the superiority of using local anesthesia with conscious sedation alone versus general anesthesia (GA) as the anesthesia management of choice for elderly frail patients. Historically, TAVI procedure is performed under GA with transesophageal echocardiography. This approach gives operators stable hemodynamic control of the patient and helps decrease the risk of many of the operation's documented complications, including paravalvular leak and valve malpositioning. However, some studies have criticized the dependence of GA on mechanical ventilation and an increased need for catecholamine and/or vasopressor agents. Alternatively, to further capitalize on the minimally invasive nature of TAVI, some authors have advocated for the use of local anesthesia (LA) and/or conscious sedation approach, which would decrease procedure time, length of hospital stay, and minimize the need for postoperative inotropes. Ultimately and at present, the choice of anesthesia is based on the personal experience and preference of the Heart Team involved in the TAVI procedure, which will dictate the best possible management plan for each patient. Many patients currently undergoing TAVI are elderly and have multiple comorbidities, making their care complex. Anesthetic care is shifting from GA to sedation and regional block, but life-threatening complications are still relatively common and safety during planning and conduct of these procedures by the heart team, with the anesthesiologist at the center, is paramount.

摘要

经导管主动脉瓣植入术(TAVI)是一种有前途的高危手术患者治疗策略,目前正在进行临床试验,以研究其在中低危患者中的疗效。关于单独使用局部麻醉加镇静与全身麻醉(GA)作为老年体弱患者首选麻醉管理的优越性,数据不一致。从历史上看,TAVI 手术是在 GA 下进行的,同时使用经食管超声心动图。这种方法可以使操作者对患者的血流动力学进行稳定控制,并有助于降低手术过程中许多有记录的并发症的风险,包括瓣周漏和瓣膜定位不当。然而,一些研究批评 GA 对机械通气的依赖性以及对儿茶酚胺和/或血管加压药物的需求增加。或者,为了进一步利用 TAVI 的微创特性,一些作者提倡使用局部麻醉(LA)和/或镇静方法,这将缩短手术时间、住院时间,并最大限度地减少术后正性肌力药物的需求。最终,目前麻醉的选择取决于参与 TAVI 手术的心脏团队的个人经验和偏好,这将为每位患者制定最佳的管理计划。目前许多接受 TAVI 的患者都是老年人,并且有多种合并症,这使得他们的治疗变得复杂。麻醉护理正在从 GA 向镇静和区域阻滞转变,但危及生命的并发症仍然相对常见,心脏团队在规划和进行这些程序时的安全性至关重要,麻醉师处于中心地位。

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