Biomedical Research Unit Zacatecas-IMSS, Instituto Mexicano Del Seguro Social, Zacatecas, Mexico.
Biomedical Research Unit Zacatecas-IMSS, Instituto Mexicano Del Seguro Social, Zacatecas, Mexico.
Pulm Pharmacol Ther. 2024 Jun;85:102300. doi: 10.1016/j.pupt.2024.102300. Epub 2024 May 7.
Over the past few decades, there has been extensive research on the use of vitamin D as an adjunctive therapy in the treatment and prevention of tuberculosis. In vitro studies have provided valuable insights into the mechanisms by which vitamin D activates the immune response to combat Mycobacterium tuberculosis. These encouraging findings have spurred clinical investigations globally to assess the effectiveness of vitamin D as a preventive measure and as an adjunctive treatment for tuberculosis. However, the results from these clinical studies have been contradictory, with some demonstrating clear efficacy while others report only modest or no activity. In this review, we aim to analyze the clinical studies on vitamin D and examine the possible discrepancies observed in their outcomes.
在过去几十年中，人们广泛研究了维生素 D 作为辅助治疗手段在结核病的治疗和预防中的应用。体外研究为维生素 D 激活免疫反应以对抗结核分枝杆菌的机制提供了有价值的见解。这些令人鼓舞的发现促使全球开展了临床研究，以评估维生素 D 作为预防措施和结核病辅助治疗的有效性。然而，这些临床研究的结果存在矛盾，一些研究表明其具有明确的疗效，而另一些研究则仅报告了适度或无活性。在本综述中，我们旨在分析关于维生素 D 的临床研究，并探讨其结果中可能存在的差异。
