Daneshvar Ramin, Naghib Maryam, Fayyazi Bordbar Mohammad Reza, Faridhosseini Farhad, Fotouhi Marziyeh, Motamed Shariati Mehrdad
Eye Research Center Mashhad University of Medical Sciences Mashhad Iran.
Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical Sciences Mashhad Iran.
Health Sci Rep. 2024 May 8;7(5):e2100. doi: 10.1002/hsr2.2100. eCollection 2024 May.
The retina is a protrusion of the brain, so researchers have recently proposed retinal changes as a new marker for studying central nervous system diseases. To investigate optic nerve head neurovascular structure assessed by optical coherence tomography angiography (OCTA) in schizophrenia compared to healthy subjects.
The study was conducted from 2019 to 2021 at the Ibn Sina Psychiatric Hospital in Mashhad, Iran. We enrolled 22 hospitalized known cases of schizophrenia, treated with risperidone as an antipsychotic drug, and 22 healthy subjects. The two groups were matched in age and gender. In the schizophrenic group, the positive and negative syndrome scale test was used to assess the illness severity. All subjects underwent complete ophthalmic evaluations and OCTA imaging.
We found that the cup/disc area ratio, vertical cup/disc ratio, and horizontal cup/disc ratio are significantly higher in patients with schizophrenia than in healthy subjects (with -values of 0.019, 0.015, and 0.022, respectively). No statistically significant difference in the peripapillary retinal nerve fiber layer and vascular parameters of the optic nerve head was observed between schizophrenia and healthy groups.
We found evidence regarding the difference in the optic nerve head tomographic properties in schizophrenia compared to healthy subjects. However, ONH vascular parameters showed no significant difference. More studies are needed for a definite conclusion.
视网膜是大脑的一个突出部分，因此研究人员最近提出将视网膜变化作为研究中枢神经系统疾病的一个新标志物。为了研究与健康受试者相比，精神分裂症患者通过光学相干断层扫描血管造影（OCTA）评估的视神经乳头神经血管结构。
该研究于2019年至2021年在伊朗马什哈德的伊本·西那精神病医院进行。我们招募了22例已知的住院精神分裂症患者，用利培酮作为抗精神病药物进行治疗，以及22名健康受试者。两组在年龄和性别上相匹配。在精神分裂症组中，使用阳性和阴性综合征量表测试来评估疾病严重程度。所有受试者均接受了完整的眼科评估和OCTA成像。
我们发现，精神分裂症患者的杯盘面积比、垂直杯盘比和水平杯盘比显著高于健康受试者（分别为0.019、0.015和0.022）。在精神分裂症组和健康组之间，未观察到视神经乳头周围视网膜神经纤维层和血管参数有统计学上的显著差异。
我们发现了与健康受试者相比，精神分裂症患者视神经乳头断层扫描特性存在差异的证据。然而，视神经乳头血管参数没有显著差异。需要更多的研究才能得出明确的结论。
