Clinic for Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Mar 2;98:109825. doi: 10.1016/j.pnpbp.2019.109825. Epub 2019 Nov 21.
Structural retinal architecture in living organisms became measurable with the development of optical coherence tomography (OCT) scanners. Single-layer analysis with spectral-domain OCT, among other techniques, may provide further insight into pathological changes in complex brain disorders such as psychosis spectrum disorders (PSD).
This study investigated potential thinning of retinal layers (retinal nerve fiber layer - RNFL, macular volume, macular thickness, ganglion cell-inner plexiform layer- GC-IPL, optic cup volume and cup-to-disk ratio) using a spectral-domain OCT device in 33 non-acute PSD patients (illness duration 5.9 ± 3.9 years) and 35 healthy controls.
In comparison to age and gender matched controls, patients had bilateral reductions in GC-IPL layer thickness and macular volume. Macular central subfield thinning was found in the right eye, while average macular thickness was lower in the left eye only. RNFL thinning was not observed in patients in comparison to controls, but we noticed that status of this layer could be affected by daily dose of antipsychotics and by illness duration.
Taken together, our results reveal that retinal thinning is present in young adults with PSDs, but in comparison to the literature we found more prominent changes in both GC-IPL and macular volume/thickness, than in RNFL. Our findings may reflect synaptic loss and neuronal atrophy in non-acute young patients with psychosis.
随着光学相干断层扫描（OCT）扫描仪的发展，活体生物的结构视网膜结构变得可测量。与其他技术相比，频域 OCT 的单层分析可能会进一步深入了解复杂脑部疾病（如精神病谱系障碍）的病理变化。
本研究使用频域 OCT 设备对 33 名非急性精神病谱系障碍患者（病程 5.9±3.9 年）和 35 名健康对照者进行了视网膜层（神经纤维层 - RNFL、黄斑体积、黄斑厚度、节细胞内丛状层 - GC-IPL、视杯体积和杯盘比）潜在变薄的研究。
与年龄和性别匹配的对照组相比，患者的 GC-IPL 层厚度和黄斑体积均出现双侧减少。右眼出现黄斑中心凹下区变薄，而左眼仅出现平均黄斑厚度降低。与对照组相比，患者的 RNFL 变薄不明显，但我们注意到该层的状态可能受抗精神病药物的日剂量和病程的影响。
综上所述，我们的研究结果表明，视网膜变薄存在于年轻的精神病谱系障碍患者中，但与文献相比，我们发现 GC-IPL 和黄斑体积/厚度的变化比 RNFL 更为明显。我们的研究结果可能反映了非急性年轻精神病患者的突触丢失和神经元萎缩。
