Garli Murat, Kurna Sevda Aydin, Gozke Eren, Yukselen Nihan Parasiz
Department of Ophthalmology, University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, İstanbul, Türkiye.
Department of Neurology, University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, İstanbul, Türkiye.
Beyoglu Eye J. 2024 Sep 1;9(3):128-136. doi: 10.14744/bej.2024.22590. eCollection 2024.
The objectives of the study are to assess the peripapillary choroidal thickness (PPCT), retinal nerve fiber layer (RNFL), and optic nerve head (ONH) parameters in multiple sclerosis (MS) patients compared to healthy subjects.
One hundred and twenty-eight eyes from 64 patients were included in this cross-sectional study. Eighty-two eyes of 41 MS patients and 46 eyes of 23 healthy subjects were examined. PPCT and RNFL were measured using spectral-domain optical coherence tomography (OCT). PPCT was measured from the four quadrants around the optic disc at a distance of 1 mm (PPCT-1) and 2 mm (PPCT-2) from the edge of the ONH and the beginning of the retinal pigment epithelium. ONH parameters were measured with Heidelberg retinal tomography (HRT-3). Disease duration, the number of episodes, MS subtypes, and Expanded Disability Status Scale (EDSS) scores were recorded.
The RNFL measurements and the mean PPCT-1 and PPCT-2 were significantly lower in MS patients compared to healthy individuals. PPCT-1 and PPCT-2 were measured as the thickest in the temporal quadrant, followed by the superior, nasal, and inferior quadrants, respectively, in both groups. When the ONH parameters were evaluated, cup/disc area ratio, cup area, and cup volume values were significantly higher, whereas optic rim volume and rim area values were significantly lower in MS patients compared to healthy subjects (p<0.05). We observed significant changes in RNFL and ONH parameters of MS patients in parallel with disease severity determined by EDSS scores and the presence of optic neuritis.
There were significant changes in RNFL thickness, PPCT, and ONH parameters when MS patients were compared with healthy subjects. Assessment of RNFL and PPCT with OCT and ONH with HRT-3 may be useful in the follow-up of MS patients.
本研究的目的是评估与健康受试者相比，多发性硬化症（MS）患者的视乳头周围脉络膜厚度（PPCT）、视网膜神经纤维层（RNFL）和视神经乳头（ONH）参数。
本横断面研究纳入了64例患者的128只眼睛。对41例MS患者的82只眼睛和23例健康受试者的46只眼睛进行了检查。使用光谱域光学相干断层扫描（OCT）测量PPCT和RNFL。在距视盘边缘1毫米（PPCT-1）和2毫米（PPCT-2）处，从视网膜色素上皮起始处测量视盘周围四个象限的PPCT。使用海德堡视网膜断层扫描（HRT-3）测量ONH参数。记录疾病持续时间、发作次数、MS亚型和扩展残疾状态量表（EDSS）评分。
与健康个体相比，MS患者的RNFL测量值以及平均PPCT-1和PPCT-2显著更低。两组中，PPCT-1和PPCT-2均在颞侧象限测量时最厚，其次分别为上方、鼻侧和下方象限。在评估ONH参数时，与健康受试者相比，MS患者的杯盘面积比、杯面积和杯容积值显著更高，而视神经边缘容积和边缘面积值显著更低（p<0.05）。我们观察到MS患者的RNFL和ONH参数随着由EDSS评分确定的疾病严重程度以及视神经炎的存在而发生显著变化。
与健康受试者相比，MS患者的RNFL厚度、PPCT和ONH参数有显著变化。使用OCT评估RNFL和PPCT以及使用HRT-3评估ONH可能对MS患者的随访有用。
