Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.
Section of Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Redox Biol. 2020 Apr;31:101489. doi: 10.1016/j.redox.2020.101489. Epub 2020 Mar 9.
Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia.
性别差异在肾脏中的氧化还原信号传递为理解肾脏的生理学和病理生理学带来了新的挑战和机遇。本综述将重点关注活性氧物种、免疫相关信号通路和内皮素-1，它们可能是肾脏氧化还原平衡性别差异的潜在介质。此外，本综述还将强调氧化还原信号在几种主要心血管和肾脏疾病中的性别差异，如急性肾损伤、糖尿病肾病、肾结石病和盐敏感性高血压。此外，我们将讨论氧化还原信号在绝经后高血压和子痫前期发病机制中的作用。
