Liu Xiaobing, Pang Peng, Luo Zhenguo, Cai Wenbo, Li Wangyang, Hao Jianhong
Department of Anaesthesiology, HongHui Hospital, Xi'an JiaoTong University, Xi'an, Shaanxi, China.
Department of Anaesthesiology, Binzhou Medical College Affiliated Hospital, Binzhou, Shandong, China.
Front Cardiovasc Med. 2024 Apr 25;11:1372268. doi: 10.3389/fcvm.2024.1372268. eCollection 2024.
This study aimed to determine the associated risk factors for proximal deep vein thrombosis (DVT) in patients with lower extremity and pelvic-acetabular fractures.
The medical records of 4,056 patients with lower extremity and pelvic-acetabular fractures were retrospectively reviewed. The patients were classified into proximal or non-proximal DVT groups. Logistic regression models were used to determine the independent risk variables for proximal DVT. The predictive value of the related risk factors was further analyzed using receiver operating characteristic curves.
The prevalence of proximal DVT was 3.16%. Sex, body mass index (BMI), fracture site, injury mechanism, diabetes, coronary heart disease (CHD), injury-to-admission interval, hematocrit, platelet counts, and D-dimer levels differed significantly between the two groups. BMI ≥ 24.0 kg/m, femoral shaft fractures, high-energy injury, diabetes, injury-to-admission interval >24 h were independent risk factors for proximal DVT. CHD decreased the risk of proximal DVT. The platelet and D-dimer had high negative predictive value for predicting proximal DVT formation, with cut-off values of 174 × 10/L and 2.18 mg/L, respectively.
BMI ≥ 24.0 kg/m, femoral shaft fractures, high-energy injury, diabetes, injury-to-admission interval >24 h were independent risk factors for proximal DVT in patients with lower extremity and pelvic-acetabular fractures. Platelet count and D-dimer level were effective indicators for excluding proximal DVT occurrence. CHD decreased the risk of proximal DVT.
本研究旨在确定下肢及骨盆髋臼骨折患者近端深静脉血栓形成（DVT）的相关危险因素。
回顾性分析4056例下肢及骨盆髋臼骨折患者的病历。将患者分为近端DVT组和非近端DVT组。采用逻辑回归模型确定近端DVT的独立风险变量。使用受试者工作特征曲线进一步分析相关危险因素的预测价值。
近端DVT的患病率为3.16%。两组患者在性别、体重指数（BMI）、骨折部位、损伤机制、糖尿病、冠心病（CHD）、受伤至入院间隔时间、血细胞比容、血小板计数及D-二聚体水平方面存在显著差异。BMI≥24.0kg/m²、股骨干骨折、高能损伤、糖尿病、受伤至入院间隔时间>24小时是近端DVT的独立危险因素。冠心病降低了近端DVT的风险。血小板和D-二聚体对预测近端DVT形成具有较高的阴性预测价值，截断值分别为174×10⁹/L和2.18mg/L。
BMI≥24.0kg/m²、股骨干骨折、高能损伤、糖尿病、受伤至入院间隔时间>24小时是下肢及骨盆髋臼骨折患者近端DVT的独立危险因素。血小板计数和D-二聚体水平是排除近端DVT发生的有效指标。冠心病降低了近端DVT的风险。
