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股骨转子间骨折患者术前深静脉血栓形成的发生率及危险因素:一项回顾性研究。

Incidence and risk factors of preoperative deep vein thrombosis in patients with intertrochanteric fractures: a retrospective study.

机构信息

State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.

Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing, 210093, Jiangsu, People's Republic of China.

出版信息

J Orthop Surg Res. 2022 Aug 3;17(1):375. doi: 10.1186/s13018-022-03268-1.

Abstract

BACKGROUND

The risk of perioperative complications remains high in patients with intertrochanteric fractures. Immobilization after injury may predispose these patients to deep vein thrombosis (DVT) while waiting for surgery. The aims of this study were to determine the incidence of preoperative DVT in patients with intertrochanteric fractures and identify independent risk factors.

METHODS

This retrospective study included patients with intertrochanteric fractures waiting for surgical interventions at our institution from June 2018 to December 2020. All patients received pharmacologic thromboprophylaxis after admission and ultrasound screening for DVT in both lower limbs before surgery. Demographic, clinical and laboratory data of these patients were collected to perform univariate analysis first. Subsequently, factors with a significant difference in univariate analysis were introduced into the multivariate logistic regression analysis to determine the independent risk factors for preoperative DVT.

RESULTS

A total of 266 patients were enrolled in this study. Seventy-one patients (26.7%) developed DVTs before surgery. The majority of DVTs were distal types (91.5%). There were 40 patients with DVTs only in the affected limb, 7 patients with DVTs only in the unaffected limb, and 24 patients with DVTs in both lower limbs. Advanced age, female, prolonged period from injury to admission, combined cranial trauma, shorter thrombin time, increased level of D-dimer and lower level of albumin proved to be the independent risk factors for preoperative DVT.

CONCLUSIONS

We observed a high incidence of preoperative DVT in patients with intertrochanteric fractures. Identification of patients at high risk may improve the prevention and treatment of preoperative DVT in this population.

摘要

背景

转子间骨折患者围手术期并发症风险仍然较高。受伤后固定可能使这些患者在等待手术时易患深静脉血栓形成(DVT)。本研究旨在确定转子间骨折患者术前 DVT 的发生率,并确定独立的危险因素。

方法

本回顾性研究纳入了 2018 年 6 月至 2020 年 12 月在我院接受手术治疗的转子间骨折患者。所有患者入院后均接受药物预防血栓形成治疗,并在术前对双侧下肢进行 DVT 超声筛查。收集这些患者的人口统计学、临床和实验室数据进行单因素分析。随后,将单因素分析中差异有统计学意义的因素纳入多因素 logistic 回归分析,以确定术前 DVT 的独立危险因素。

结果

共纳入 266 例患者。71 例(26.7%)患者在术前发生 DVT。大多数 DVT 为远端型(91.5%)。受累肢 DVT 40 例,非受累肢 DVT 7 例,双下肢 DVT 24 例。高龄、女性、受伤至入院时间延长、合并颅脑损伤、凝血酶时间缩短、D-二聚体水平升高、白蛋白水平降低是术前 DVT 的独立危险因素。

结论

我们观察到转子间骨折患者术前 DVT 的发生率较高。识别高危患者可能有助于改善该人群术前 DVT 的预防和治疗。

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