Caputo G R, Graham M M, Brust K D, Kennedy J W, Nelp W B
Am J Cardiol. 1985 Nov 1;56(12):781-6. doi: 10.1016/0002-9149(85)91136-1.
A count-based method for measuring left ventricular (LV) volume using technetium-99m-labeled red cells and ungated single-photon emission computed tomography is described. The tomographic slices were used to determine the counts per milliliter in the center of the left ventricle and total LV counts, which were used to derive mean LV volume. End-diastolic and end-systolic volumes were calculated from the mean volume using the LV time-activity curve from planar gated blood pool images. Phantom evaluation with simulated LV volumes (50 to 400 ml) in air, in a phantom filled with water, with 10% background, and with a simulated right ventricle, showed excellent accuracy. For clinical validation, 30 patients underwent electrocardiographically gated planar and nongated tomographic acquisition of the cardiac blood pool followed by single-plane cineangiography. For end-diastolic and end-systolic volumes combined, the correlation with cineangiography showed a standard error of the estimate (SEE) of 24 ml and 14 ml, respectively. Mean intra- and interobserver deviation was 12 ml and 14 ml (SEE 13 ml and 16 ml), respectively. It is concluded that this noninvasive count-based technique, requiring no assumptions regarding LV geometry, is an accurate and reproducible way to measure LV volume.
描述了一种使用锝-99m标记的红细胞和非门控单光子发射计算机断层扫描测量左心室（LV）容积的基于计数的方法。断层切片用于确定左心室中心每毫升的计数和左心室总计数，这些用于推导左心室平均容积。舒张末期和收缩末期容积通过使用平面门控血池图像的左心室时间-活性曲线从平均容积计算得出。在空气中、充满水的模体中、有10%背景以及有模拟右心室的情况下，对模拟左心室容积（50至400毫升）进行模体评估，显示出极佳的准确性。为进行临床验证，30例患者接受了心电图门控的心脏血池平面和非门控断层扫描采集，随后进行单平面电影血管造影。对于舒张末期和收缩末期容积的总和，与电影血管造影的相关性显示估计标准误差（SEE）分别为24毫升和14毫升。观察者内和观察者间的平均偏差分别为12毫升和14毫升（SEE分别为13毫升和16毫升）。得出的结论是，这种基于计数的非侵入性技术，无需对左心室几何形状做任何假设，是测量左心室容积的一种准确且可重复的方法。
