Hayek Abdulkader, Sridhar Sathvik B, Rabbani Syed Arman, Shareef Javed, Wadhwa Tarun
Department of Clinical Pharmacy and Pharmacology, RAK College of Pharmacy, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates.
SAGE Open Med. 2024 May 8;12:20503121241249908. doi: 10.1177/20503121241249908. eCollection 2024.
Healthcare professionals' awareness of adverse drug reaction reporting and pharmacovigilance practices differ by country. The study assesses healthcare professionals' knowledge, practice, and potential barriers to pharmacovigilance-related practices and reporting adverse drug reaction.
A cross-sectional investigation was conducted in government and private healthcare settings. The study included licensed physicians, pharmacists, and nurses. To examine knowledge, practice, and potential barriers to pharmacovigilance-related practices and adverse drug reaction reporting, a 22-item validated questionnaire was used.
The final analysis included 311 healthcare professionals. Most healthcare professionals, 59% ( = 182), mentioned encountering patients with adverse drug reactions during the last year. On the other hand, most healthcare professionals, 54% ( = 167), mentioned that they had not reported adverse drug reactions. A good proportion of respondents mentioned that it is essential to report adverse drug reactions ( = 288, 92.6%), availability of adverse drug reactions reporting forms in practice sites ( = 216, 69.5%), had awareness regarding how to report adverse drug reactions ( = 221, 71.1%), the necessity of reporting minor/less important adverse drug reactions ( = 265, 85.2%), and were trained on how to report adverse drug reactions ( = 201, 64.6%). Adverse drug reaction reporting program in the United Arab Emirates ( = 148, 47.6) was known to many healthcare professionals. Lack of time was the major impediment to reporting adverse drug reactions at 42.7% ( = 133). The predictor variable work experience does add to the model ( < 0.05) concerning association with filling of adverse drug reaction forms (Estimate = 0.380; SE = 0.452; = 0.400), professional role (Estimate = 0.454; SE = 0.673; = 0.500). In addition, the predictor variable practice setting adds to the model ( < 0.05) concerning the knowledge regarding the availability of adverse drug reaction reporting forms (Estimate = -1.229; SE = 0.298; = 0.000), training on how to report adverse drug reactions (Estimate = -0.660; SE = 0.294; = 0.025), and awareness regarding the adverse drug reaction reporting program in the United Arab Emirates (Estimate = -1.032; SE = 0.280; = 0.000).
Pharmacists had the most knowledge regarding adverse drug reaction reporting and pharmacovigilance. The underreporting of adverse drug reactions was documented among physicians and nurses. Lack of time was the most significant barrier to reporting adverse drug reactions, followed by uncertainty and complicated adverse drug reaction documentation forms.
医疗保健专业人员对药品不良反应报告和药物警戒实践的认识因国家而异。本研究评估了医疗保健专业人员在药物警戒相关实践和报告药品不良反应方面的知识、实践情况及潜在障碍。
在政府和私立医疗保健机构中进行了一项横断面调查。研究对象包括执业医师、药剂师和护士。为了调查药物警戒相关实践和药品不良反应报告的知识、实践情况及潜在障碍，使用了一份经过验证的包含22个条目的问卷。
最终分析纳入了311名医疗保健专业人员。大多数医疗保健专业人员，即59%（n = 182），提到在过去一年中遇到过有药品不良反应的患者。另一方面，大多数医疗保健专业人员，即54%（n = 167），表示他们未曾报告过药品不良反应。相当一部分受访者提到报告药品不良反应至关重要（n = 288，92.6%）、在实际工作场所可获取药品不良反应报告表（n = 216，69.5%）、了解如何报告药品不良反应（n = 221，71.1%）、报告轻微/不太重要的药品不良反应的必要性（n = 265，85.2%），并且接受过如何报告药品不良反应的培训（n = 201，64.6%）。许多医疗保健专业人员知晓阿拉伯联合酋长国的药品不良反应报告项目（n = 148，47.6%）。时间不足是报告药品不良反应的主要障碍，占42.7%（n = 133）。预测变量工作经验在与填写药品不良反应表格的关联方面确实增加了模型（p < 0.05）（估计值 = 0.380；标准误 = 0.452；p = 0.400）、专业角色（估计值 = 0.454；标准误 = 0.673；p = 0.500）。此外，预测变量实践场所增加了模型（p < 0.05），涉及对药品不良反应报告表可获取性的了解（估计值 = -1.229；标准误 = 0.298；p = 0.000）、关于如何报告药品不良反应的培训（估计值 = -0.660；标准误 = 0.294；p = 0.025）以及对阿拉伯联合酋长国药品不良反应报告项目的了解（估计值 = -1.032；标准误 = 0.280；p = 0.000）。
药剂师在药品不良反应报告和药物警戒方面知识最为丰富。医师和护士中存在药品不良反应报告不足的情况。时间不足是报告药品不良反应最主要的障碍，其次是不确定性和复杂的药品不良反应记录表格。
