Khanna Kanika, Welch Matthew D
Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States.
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States.
MicroPubl Biol. 2024 Apr 24;2024. doi: 10.17912/micropub.biology.001178. eCollection 2024.
species belonging to the pseudomallei group include significant human and animal pathogens as well as the non-pathogenic species . These bacteria co-opt the host cell machinery for their replication and spread between host cells. Thus, it is of interest to understand the structural features of these cells that contribute to host cell colonization and virulence. This study provides high-resolution cryo-electron tomograms of stationary phase . It reveals the presence of compact nucleoids and storage granules, as well as examples of the type III secretion system and chemoreceptor arrays. The data can be used to investigate the near-atomic structure of stationary-phase bacterial macromolecules, such as ribosomes.
类鼻疽杆菌属的细菌包括重要的人类和动物病原体以及非致病物种。这些细菌利用宿主细胞机制进行复制并在宿主细胞间传播。因此，了解这些有助于宿主细胞定殖和毒力的细胞结构特征很有意义。本研究提供了稳定期的高分辨率冷冻电子断层扫描图。它揭示了致密类核和储存颗粒的存在，以及III型分泌系统和化学感受器阵列的实例。这些数据可用于研究稳定期细菌大分子（如核糖体）的近原子结构。
