Tesfaye Ephrem, Getnet Mihret, Anmut Bitew Desalegn, Adugna Dagnew Getnet, Maru Lemlemu
Department of Biomedical Sciences, Madda Walabu University Goba Referral Hospital, Bale-Robe, Ethiopia.
Department of Human Physiology, School of Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Front Neurosci. 2024 Apr 24;18:1383355. doi: 10.3389/fnins.2024.1383355. eCollection 2024.
Functional connectivity (FC) is the correlation between brain regions' activities, studied through neuroimaging techniques like fMRI. It helps researchers understand brain function, organization, and dysfunction. Hyperthyroidism, characterized by high serum levels of free thyroxin and suppressed thyroid stimulating hormone, can lead to mood disturbance, cognitive impairment, and psychiatric symptoms. Excessive thyroid hormone exposure can enhance neuronal death and decrease brain volume, affecting memory, attention, emotion, vision, and motor planning.
We conducted thorough searches across Google Scholar, PubMed, Hinari, and Science Direct to locate pertinent articles containing original data investigating FC measures in individuals diagnosed with hyperthyroidism.
The systematic review identified 762 articles, excluding duplicates and non-matching titles and abstracts. Four full-text articles were included in this review. In conclusion, a strong bilateral hippocampal connection in hyperthyroid individuals suggests a possible neurobiological influence on brain networks that may affect cognitive and emotional processing.
PROSPERO, CRD42024516216.
功能连接性（FC）是脑区活动之间的相关性，通过功能磁共振成像（fMRI）等神经成像技术进行研究。它有助于研究人员了解大脑功能、组织和功能障碍。甲状腺功能亢进症的特征是血清游离甲状腺素水平升高和促甲状腺激素受到抑制，可导致情绪障碍、认知障碍和精神症状。甲状腺激素暴露过多会增加神经元死亡并减少脑容量，影响记忆、注意力、情绪、视觉和运动规划。
我们在谷歌学术、PubMed、Hinari和科学Direct上进行了全面搜索，以找到包含调查甲状腺功能亢进症患者FC测量的原始数据的相关文章。
系统评价共识别出762篇文章，排除重复以及标题和摘要不匹配的文章。本评价纳入了4篇全文文章。总之，甲状腺功能亢进症患者双侧海马体存在较强连接，这表明对脑网络可能存在神经生物学影响，可能会影响认知和情绪处理。
PROSPERO，CRD42024516216。
