中青年急性脑梗死中重度饮酒的临床特征：一项12个月的随访研究。

Clinical characteristics of heavy alcohol consumption in young and middle-aged acute cerebral infarction: A 12-month follow-up study.

作者信息

Liao Jia, Li Xin, Wang Ling, Chen Mingfen, Quan Fengying, Xi Zhiqin

机构信息

Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

College of Nursing, Chongqing Medical University, Chongqing, China.

出版信息

Heliyon. 2024 Apr 26;10(9):e30416. doi: 10.1016/j.heliyon.2024.e30416. eCollection 2024 May 15.

DOI:10.1016/j.heliyon.2024.e30416

PMID:38726157

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11079088/

Abstract

OBJECTIVE

To investigate the clinical characteristics and prognosis of heavy alcohol consumption among young and middle-aged patients with acute cerebral infarction (ACI).

METHODS

A total of 263 young and middle-aged ACI patients were included in the study from June 2018 to December 2020 and classified into heavy drinkers and non-heavy drinkers. Multivariate logistic regression analysis was conducted to assess the association between ACI and heavy alcohol consumption, considering clinical characteristics and one-year post-discharge prognosis.

RESULTS

Among the patients, 78 were heavy drinkers. Heavy drinkers were more likely to consume alcohol 24 h before ACI onset (OR 4.03, 95 % CI 2.26-7.20), especially in the form of liquor (OR 3.83, 95 % CI 1.59-9.20), and had a higher risk of diastolic blood pressure ≥90 mmHg upon admission (OR 2.02, 95 % CI 1.12-3.64). In the one-year post-discharge prognosis, heavy drinkers had a greater likelihood of poor prognosis at 3 months (OR 2.31, 95 % CI 1.01-5.25), were less likely to quit drinking after discharge (OR 0.36, 95 % CI 0.19-0.66), and had a higher risk of recurrent cerebral infarction (OR 2.79, 95 % CI 1.14-6.84).

CONCLUSIONS

Over the 12-month follow-up, young and middle-aged ACI patients with heavy alcohol consumption exhibited worse short-term prognosis. Controlling alcohol consumption levels may improve the prognosis of these patients.

摘要

目的

探讨中青年急性脑梗死（ACI）患者大量饮酒的临床特征及预后。

方法

选取2018年6月至2020年12月期间的263例中青年ACI患者，分为大量饮酒者和非大量饮酒者。采用多因素logistic回归分析评估ACI与大量饮酒之间的关联，并考虑临床特征及出院后1年的预后情况。

结果

患者中78例为大量饮酒者。大量饮酒者在ACI发病前24小时饮酒的可能性更高（比值比[OR]4.03，95%置信区间[CI]2.26 - 7.20），尤其是饮用白酒的形式（OR 3.83，95% CI 1.59 - 9.20），且入院时舒张压≥90 mmHg的风险更高（OR 2.02，95% CI 1.12 - 3.64）。在出院后1年的预后中，大量饮酒者在3个月时预后不良的可能性更大（OR 2.31，95% CI 1.01 - 5.25），出院后戒酒的可能性更小（OR 0.36，95% CI 0.19 - 0.66），复发性脑梗死的风险更高（OR 2.79，95% CI 1.14 - 6.84）。