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一种来自1-3的新型环状细菌素的特性及其对……的作用模式。

Characterization of a novel circular bacteriocin from 1-3, and its mode of action against .

作者信息

Zhang Jun, Zhao Lihong, Tang Wei, Li Jiaxin, Tang Tao, Sun Xiaowen, Qiao Xiaoni, He Zengguo

机构信息

School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.

Qingdao Bioantai Biotechnology Co., Ltd., Qingdao, 266071, China.

出版信息

Heliyon. 2024 Apr 22;10(9):e29701. doi: 10.1016/j.heliyon.2024.e29701. eCollection 2024 May 15.

DOI:10.1016/j.heliyon.2024.e29701
PMID:38726204
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11078769/
Abstract

In this study, isolate 1-3 was selected out for its anti- Listeria potency, from which a novel circular bacteriocin, velezin, was purified out of the fermentate, and then characterized. Facilitated with a broad antibacterial spectrum, velezin has demonstrated decent inhibitive activity against of foodborne pathogen ATCC 19115. It exerted the antibacterial activity through damaging the membrane integrity of targeted cell and causing leakage of vital elements, including K ion. It was noteworthy that velezin also inhibited the biofilm formation by ATCC 19115. At the challenge of velezin, ATCC 19115 up-regulated expression of genes associated with membrane, ion transporters, stressing-related proteins as well as the genes responsible for the synthesis of small molecule. Taken together, velezin may have potential to be a candidate as natural additive used in food/feed in the future.

摘要

在本研究中，分离株1-3因其抗李斯特菌效力而被选出，从其发酵产物中纯化出一种新型环状细菌素——维勒津，然后对其进行表征。维勒津具有广泛的抗菌谱，已证明对食源性病原体ATCC 19115具有良好的抑制活性。它通过破坏靶细胞的膜完整性并导致包括钾离子在内的重要元素泄漏来发挥抗菌活性。值得注意的是，维勒津还抑制了ATCC 19115生物膜的形成。在维勒津的作用下，ATCC 19115上调了与膜、离子转运体、应激相关蛋白以及负责小分子合成的基因的表达。综上所述，维勒津未来可能有潜力成为食品/饲料中使用的天然添加剂候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/78d40be86dab/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/e8cdf033aae8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/6027d3fecc4c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/72d6dfab3645/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/45c93980dd2e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/378f1c6f3e60/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/328a78651534/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/f2ee70979e5e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/78d40be86dab/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/e8cdf033aae8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/6027d3fecc4c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/72d6dfab3645/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/45c93980dd2e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/378f1c6f3e60/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/328a78651534/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/f2ee70979e5e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4115/11078769/78d40be86dab/gr8.jpg

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