Vaca Jessica, Ortiz Aurelio, Sansinenea Estibaliz
Facultad De Ciencias Químicas, Benemérita Universidad Autónoma De Puebla, 72590 Puebla; Pue, México.
Curr Med Chem. 2022;29(12):2093-2108. doi: 10.2174/0929867328666210527093041.
Currently antibiotic resistant pathogenic bacteria are emerging as an important health problem worldwide. The search for new compounds with antibiotic characteristics is the most promising alternative. Bacteriocins are natural compounds that are inhibitory against pathogens, and Bacillus species are the major producers of these compounds, showing antimicrobial activity against clinically important bacteria. These peptides not only have potential in the pharmaceutical industry but also in food and agricultural sectors.
We provide an overview of the recent bacteriocins isolated from different species of Bacillus including their applications and older bacteriocins.
In this review, we have revised some works about the improvements carried out in the production of bacteriocins.
These applications make bacteriocins very promising compounds that need to study for industrial production.
目前，抗生素耐药病原菌正在成为全球范围内一个重要的健康问题。寻找具有抗生素特性的新化合物是最有前景的替代方法。细菌素是对病原体具有抑制作用的天然化合物，芽孢杆菌属是这些化合物的主要生产者，对临床上重要的细菌表现出抗菌活性。这些肽不仅在制药行业有潜力，在食品和农业领域也有潜力。
我们综述了最近从不同芽孢杆菌物种中分离出的细菌素，包括它们的应用以及较早期的细菌素。
在本综述中，我们回顾了一些关于细菌素生产改进方面的研究工作。
这些应用使细菌素成为非常有前景的化合物，需要对其进行工业生产研究。
