Li Denghui, Zhang Mengjie, Liu Ju, Li Zhifang, Ni Bing
Department of Pathophysiology, College of High Altitude Military Medicine, Third Military Medical University Chongqing 400038, China.
Department of Foreign Languages, College of Basic Medical Sciences, Third Military Medical University Chongqing 400038, China.
Am J Cancer Res. 2024 Apr 15;14(4):1446-1465. doi: 10.62347/SIGP9279. eCollection 2024.
Liver cancer ranks as the third leading cause of cancer-related mortality worldwide, predominantly in the form of hepatocellular carcinoma (HCC). Conventional detection and treatment approaches have proven inadequate for addressing the elevated incidence and mortality rates associated with HCC. However, a significant body of research suggests that combating HCC through the induction of ferroptosis is possible. Ferroptosis is a regulated cell death process characterized by elevated levels of reactive oxygen species (ROS) and lipid peroxide accumulation, both of which are dependent on iron levels. In recent years, there has been an increasing focus on investigating ferroptosis, revealing its potential as an inhibitory mechanism against various diseases, including tumors. Therefore, ferroptosis induction holds great promise for treating multiple types of cancers, including HCC. This article provides a review of the key mechanisms involved in ferroptosis and explores the potential application of multiple targets and pathways associated with ferroptosis in HCC treatment to improve therapeutic outcomes.
肝癌是全球癌症相关死亡的第三大主要原因，主要表现为肝细胞癌（HCC）。传统的检测和治疗方法已被证明不足以应对与HCC相关的发病率和死亡率上升问题。然而，大量研究表明，通过诱导铁死亡来对抗HCC是可行的。铁死亡是一种受调控的细胞死亡过程，其特征是活性氧（ROS）水平升高和脂质过氧化物积累，这两者都依赖于铁水平。近年来，对铁死亡的研究越来越受到关注，揭示了其作为针对包括肿瘤在内的各种疾病的抑制机制的潜力。因此，诱导铁死亡在治疗包括HCC在内的多种癌症方面具有很大的前景。本文综述了铁死亡涉及的关键机制，并探讨了与铁死亡相关的多个靶点和途径在HCC治疗中的潜在应用，以改善治疗效果。
