甘油对豚鼠水肿耳的影响。

The effect of glycerol on the guinea-pig hydropic ear.

作者信息

Magliulo G, Ungari C, Della Rocca C, Muscatello M, Vingolo G M

机构信息

2nd ENT Department, University La Sapienza, Rome, Italy.

出版信息

Clin Otolaryngol Allied Sci. 1991 Oct;16(5):483-7. doi: 10.1111/j.1365-2273.1991.tb01045.x.

DOI:10.1111/j.1365-2273.1991.tb01045.x

PMID:1742898

Abstract

The aim of this paper was to investigate the effect of glycerol on experimental endolymphatic hydrops in guinea-pigs. The right endolymphatic sac and duct were obliterated through an extradural posterior fossa approach. Some animals received a 3 g/kg dose of glycerol for a period of 7 days, whereas others received the same dose for 30 days. The activity of glycerol was studied by investigating the volumetric changes in the scala media determined with a computerized planimeter. Glycerol induced a significant reduction of the hydrops showing its effectiveness and suggesting a strial metabolic response.

摘要

本文旨在研究甘油对豚鼠实验性内淋巴积水的影响。通过硬脑膜后颅窝入路闭塞右侧内淋巴囊和导管。一些动物接受3 g/kg剂量的甘油，持续7天，而其他动物接受相同剂量30天。通过用计算机化面积测量仪测定中阶的容积变化来研究甘油的作用。甘油使积水显著减少，显示出其有效性，并提示了血管纹的代谢反应。