Evans S F, Nisbet N W, Marshall M J, Catty D
Br J Exp Pathol. 1985 Apr;66(2):251-5.
The response of T and B lymphocytes to the mitogens PHA and LPS was studied in the Fatty/Orl-op rat. Whereas T and B cells from op/op spleen showed no lack of responsiveness compared with that of normal (op/+) littermate rats, the response of thymic cells to the T cell mitogen was lower in op/op rats over 12 days of age compared with normal rats of the same age. Osteopetrotic rats of 10 days and younger did not show this T cell deficiency. The responsiveness of T cells from op/op lymph nodes to PHA was less than that of normal rats at 12 days and older. Thus, though splenic T and B cell populations were well maintained in the adult op/op rat despite the severe depletion of marrow cells in this mutant, the thymus and lymph node T cell populations were qualitatively or quantitatively deficient. Since osteopetrotic obliteration of the marrow cavities precedes the appearance of the immune deficiency we suggest that the immune deficiency may be caused by a failure of T cell supply to the thymus and lymph nodes.
在脂肪/骨硬化（Fatty/Orl-op）大鼠中研究了T淋巴细胞和B淋巴细胞对有丝分裂原PHA和LPS的反应。与正常（op/+）同窝大鼠相比，op/op大鼠脾脏中的T细胞和B细胞未表现出反应性缺乏，但12日龄以上的op/op大鼠胸腺细胞对T细胞有丝分裂原的反应低于同龄正常大鼠。10日龄及更小的骨硬化大鼠未表现出这种T细胞缺陷。12日龄及以上的op/op大鼠淋巴结T细胞对PHA的反应性低于正常大鼠。因此，尽管在这种突变体中骨髓细胞严重耗竭，但成年op/op大鼠脾脏中的T细胞和B细胞群体仍能良好维持，胸腺和淋巴结T细胞群体在质量或数量上存在缺陷。由于骨髓腔的骨硬化闭塞先于免疫缺陷的出现，我们认为免疫缺陷可能是由于胸腺和淋巴结的T细胞供应不足所致。
