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Failure of thymic grafts to stimulate resorption of bone in the Fatty/Orl-op rat.

作者信息

Nisbet N W, Waldron S F, Marshall M J

出版信息

Calcif Tissue Int. 1983;35(1):122-5. doi: 10.1007/BF02405017.

DOI:10.1007/BF02405017
PMID:6839186
Abstract

An infusion of compatible normal bone marrow stimulated bone resorption in both unthymectomized and thymectomized Fatty/Orl-op osteopetrotic rats. Bone resorption was not stimulated by compatible normal thymic grafts in either unthymectomized or thymectomized mutants. It is concluded that the thymus is not fundamental in the cure of osteopetrosis in this strain of osteopetrotic rat and that the defect lies in myeloid rather than thymic regulation of osteoclastic function.

摘要

相似文献

1
Failure of thymic grafts to stimulate resorption of bone in the Fatty/Orl-op rat.
Calcif Tissue Int. 1983;35(1):122-5. doi: 10.1007/BF02405017.
2
[Curing of the congenital osteopetrosis of "op" rats by thymus grafts].
C R Acad Hebd Seances Acad Sci D. 1976 Sep 20;283(5):531-3.
3
Bone absorption and the immune system.骨吸收与免疫系统。
Scand J Immunol. 1981 Dec;14(6):599-605. doi: 10.1111/j.1365-3083.1981.tb00601.x.
4
A secondary immune deficiency in the Fatty/Orl-op rat.肥胖/奥勒普大鼠的继发性免疫缺陷。
Br J Exp Pathol. 1985 Apr;66(2):251-5.
5
Heterotopically induced osteogenesis in osteopetrotic rat mutants. A preliminary report.骨石化大鼠突变体中的异位诱导成骨。初步报告。
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6
[Involvement of the spleen in congenital osteopetrosis of the "op" rat: corrective effect of thymus grafts].
C R Acad Hebd Seances Acad Sci D. 1976 Oct 18;283(9):1073-6.
7
Effects of bone marrow transplantation on impacted dental germs in osteopetrotic op/op rats.
J Oral Pathol Med. 1989 Mar;18(3):163-6. doi: 10.1111/j.1600-0714.1989.tb00755.x.
8
Indefinite survival of skin allografts in adult thymectomized, antilymphocyte serum-treated mice given bone marrow and thymus grafts of donor origin: tolerance induction by donor bone marrow and thymus.成年去胸腺、抗淋巴细胞血清处理的小鼠接受供体来源的骨髓和胸腺移植后皮肤同种异体移植物的长期存活:供体骨髓和胸腺诱导的耐受性。
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10
Immunological defect and its correction in the osteopetrotic mutant rat.骨石化突变大鼠的免疫缺陷及其纠正
Proc Natl Acad Sci U S A. 1977 Jan;74(1):339-42. doi: 10.1073/pnas.74.1.339.

引用本文的文献

1
Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2.骨硬化症(op)大鼠遗传损伤的精细基因组定位及三个定位和功能候选基因Clcn7、Atp6v0c和Slc9a3r2的排除。
Calcif Tissue Int. 2009 May;84(5):355-60. doi: 10.1007/s00223-009-9229-7. Epub 2009 Mar 4.
2
Skeletal resistance to 1,25-dihydroxyvitamin D3 in osteopetrotic rats.骨石化症大鼠骨骼对1,25 - 二羟维生素D3的抵抗性
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A secondary immune deficiency in the Fatty/Orl-op rat.

本文引用的文献

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The origin of osteoclasts.破骨细胞的起源。
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Osteoclasts derive from hematopoietic stem cells according to marker, giant lysosomes of beige mice.根据标记物(米色小鼠的巨大溶酶体),破骨细胞起源于造血干细胞。
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Control of bone resorption by hematopoietic tissue. The induction and reversal of congenital osteopetrosis in mice through use of bone marrow and splenic transplants.造血组织对骨吸收的控制。通过骨髓和脾脏移植诱导并逆转小鼠先天性骨质石化症。
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The osteoclast: review of ultrastructure, origin, and structure-function relationship.破骨细胞:超微结构、起源及结构-功能关系综述
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