Nutrigenomics Section, Institute of Nutritional Sciences, Friedrich-Schiller-Universität Jena, 07743 Jena, Germany.
Cells. 2024 Apr 23;13(9):727. doi: 10.3390/cells13090727.
Cellular and organismic copper (Cu) homeostasis is regulated by Cu transporters and Cu chaperones to ensure the controlled uptake, distribution and export of Cu ions. Many of these processes have been extensively investigated in mammalian cell culture, as well as in humans and in mammalian model organisms. Most of the human genes encoding proteins involved in Cu homeostasis have orthologs in the model organism, (). Starting with a compilation of human Cu proteins and their orthologs, this review presents an overview of Cu homeostasis in , comparing it to the human system, thereby establishing the basis for an assessment of the suitability of as a model to answer mechanistic questions relating to human Cu homeostasis.
细胞和生物体内铜 (Cu) 的稳态是由 Cu 转运蛋白和 Cu 伴侣蛋白来调控的，以确保 Cu 离子的摄取、分布和外排受到控制。这些过程中的许多已经在哺乳动物细胞培养中、人类和哺乳动物模型生物中得到了广泛的研究。大多数参与 Cu 稳态的人类基因编码的蛋白在模型生物中都有同源物，（）。从人类 Cu 蛋白及其同源物的汇编开始，本综述概述了 在 Cu 稳态中的作用，将其与人类系统进行比较，从而为评估 作为回答与人类 Cu 稳态相关的机制问题的模型的适用性奠定了基础。
