Sudakov K V, Belova T I, Yumatov J A
Endocrinol Exp. 1985 Mar;19(1):39-45.
Blood pressure and heart rate were measured under the conditions of prolonged emotional stress due to 30 h immobilization in rats of various strain: 1. Wistar; 2. Veg (deviated from Wistar); 3. August; 4. Bastards. Some defined areas of brain from Wistar and August rats were dissected and used for the estimation of noradrenaline (NA) and dopamine (DA) content with the aid of spectrofluorimetric method. It was found that, among the animals of all strains used, different groups may be defined according to their resistance to cardiovascular changes due to emotional stress. Thus, the highest percentage of resistant animals was found among Wistar rats, while the lowest one occurred in August animals. Intact August rats differ from those of Wistar strain by a lower content of NA in hypothalamus and a higher content of DA in midbrain and isthmus. Sensitive animals of August strain showed an increase of DA content in hypothalamus and bulb compared to intact animals and a decrease of DA content compared to operated controls, while no such changes were observed in Wistar rats. However, sensitive Wistar rats showed an increase of DA content in midbrain.
在多种品系大鼠因30小时固定不动而导致长期情绪应激的条件下，测量其血压和心率：1. 威斯塔大鼠；2. 维格大鼠（偏离威斯塔大鼠）；3. 奥古斯特大鼠；4. 杂种大鼠。解剖了威斯塔大鼠和奥古斯特大鼠大脑的一些特定区域，并借助荧光分光光度法估算去甲肾上腺素（NA）和多巴胺（DA）的含量。结果发现，在所有使用的品系动物中，可根据它们对情绪应激引起的心血管变化的抵抗力来划分不同的组。因此，在威斯塔大鼠中发现抗性动物的比例最高，而在奥古斯特大鼠中最低。完整的奥古斯特大鼠与威斯塔品系大鼠的不同之处在于，其下丘脑的NA含量较低，中脑和峡部的DA含量较高。与完整动物相比，奥古斯特品系的敏感动物下丘脑和延髓中的DA含量增加，与手术对照组相比DA含量降低，而在威斯塔大鼠中未观察到此类变化。然而，敏感的威斯塔大鼠中脑的DA含量增加。
