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[情绪应激早期的脑儿茶酚胺]

[Brain catecholamines at the early stage of emotional stress].

作者信息

Belova T I, Anokhina I P, Ivanova T M, Boliakin V I

出版信息

Biull Eksp Biol Med. 1979 Sep;88(9):275-8.

PMID:574784
Abstract

The blood pressure (BP) dynamics and catecholamine (CA) levels in the brain regions of August and Wistar rats were studied two hours after immobilization in order to elucidate the central neurochemical mechanisms leading to the destruction of BR self-regulation under emotional stress during the experiment. The BP level did not differ from the normal. The CA concentration in the hypothalamus, midbrain, isthmus rhombencephali and medulla oblongata underwent considerable changes. It is suggested that the mechanism of the CA changes in both strains of the rats exposed to stress is similar in the hypothalamus and medulla oblongata while both strains of the rats studied showed specificity in the activity of NA-synthesizing neurons of the isthmus rhombencephali and DA-synthesizing neurons of the midbrain that might be a cause of different resistance of cardiovascular functions during the later stage of immobilization.

摘要

为了阐明实验中情绪应激下导致血压(BP)自身调节破坏的中枢神经化学机制,在将八月龄大鼠和Wistar大鼠固定两小时后,研究了它们脑区的血压动态和儿茶酚胺(CA)水平。血压水平与正常情况无差异。下丘脑、中脑、菱脑峡和延髓中的CA浓度发生了显著变化。有人认为,在应激状态下,两种品系大鼠下丘脑和延髓中CA变化的机制相似,而所研究的两种品系大鼠在菱脑峡去甲肾上腺素合成神经元和中脑多巴胺合成神经元的活性方面均表现出特异性,这可能是固定后期心血管功能不同抵抗力的原因。

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