Department of Publication and Extension, Kampala International University, Kampala, Uganda.
Medicine (Baltimore). 2024 May 10;103(19):e38088. doi: 10.1097/MD.0000000000038088.
Microbiota modulation, the intentional change in the structure and function of the microbial community, is an emerging trajectory that holds the promise to mitigate an infinite number of health issues. The present review illustrates the underlying principles of microbiota modulation and the various applications of this fundamental process to human health, healthcare management, and pharmacologic interventions. Different strategies, directing on dietary interventions, fecal microbiota transplantation, treatment with antibiotics, bacteriophages, microbiome engineering, and modulation of the immune system, are described in detail. This therapeutic implication is reflected in clinical applications to gastrointestinal disorders and immune-mediated diseases for microbiota-modulating agents. In addition to this, the review outlines the challenges of translating researched outcomes into clinical practice to consider safety and provides insights into future research directions of this rapidly developing area.
微生物组调节，即有意改变微生物群落的结构和功能，是一个新兴的领域，有望缓解无数健康问题。本综述说明了微生物组调节的基本原理，以及这一基本过程在人类健康、医疗保健管理和药物干预方面的各种应用。详细描述了不同的策略，包括饮食干预、粪便微生物群移植、抗生素、噬菌体、微生物组工程和免疫系统调节。这种治疗意义反映在用于调节微生物群的药物在胃肠道疾病和免疫介导性疾病的临床应用中。除此之外，该综述还概述了将研究成果转化为临床实践时需要考虑安全性的挑战，并为这一快速发展领域的未来研究方向提供了思路。
