Heininger Ulrich, Martini Helena, Eeuwijk Jennifer, Prokić Ivana, Guignard Adrienne P, Turriani Elisa, Duchenne Maurine, Berlaimont Valérie
Department of Pediatric Infectious Diseases and Vaccinology, University of Basel Children's Hospital, Basel, Switzerland.
Department of Microbiology, National Reference Centre for Bordetella pertussis, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2435134. doi: 10.1080/21645515.2024.2435134. Epub 2024 Dec 17.
Pertussis resurgence has been documented even in countries with high pediatric vaccine coverage. The proportion of isolates not expressing pertactin (PRN) has increased in several countries where acellular pertussis (aP) vaccines are used. We systematically reviewed published literature up to July 2023 on PRN-negative isolates in MEDLINE and Embase with no geographical limitations, complemented with a gray literature search. An increase in the proportion of PRN-negative isolates was observed in countries where aP vaccines were used, while such isolates seem to be absent in countries using whole-cell pertussis vaccination. We reviewed the data supporting aP vaccine-driven evolution of , explored the effects of PRN deficiency on the clinical presentation of pertussis, summarized the evidence for preserved aP vaccine effectiveness, and proposed actions to further improve assessment of the clinical significance of PRN deficiency and its potential impact on pertussis prevention.
即使在儿童疫苗接种覆盖率高的国家，百日咳疫情也有复发的记录。在几个使用无细胞百日咳（aP）疫苗的国家，不表达百日咳黏附素（PRN）的分离株比例有所增加。我们系统检索了截至2023年7月发表在MEDLINE和Embase上的关于PRN阴性分离株的文献，检索无地域限制，并辅以灰色文献搜索。在使用aP疫苗的国家，观察到PRN阴性分离株的比例有所增加，而在使用全细胞百日咳疫苗的国家似乎不存在此类分离株。我们回顾了支持aP疫苗驱动的PRN进化的数据，探讨了PRN缺乏对百日咳临床表现的影响，总结了aP疫苗有效性得以维持的证据，并提出了进一步改进对PRN缺乏的临床意义及其对百日咳预防潜在影响评估的行动建议。
