Department of Microbiology, Trauma Centre, AIIMS, New Delhi, India.
Department of Laboratory Medicine, Trauma Centre, AIIMS, New Delhi, India.
J Infect Dev Ctries. 2024 Apr 30;18(4):636-639. doi: 10.3855/jidc.18517.
Kodamaea ohmeri is a rare, recognized pathogen that has previously been isolated from environmental sources. The patients commonly affected by this yeast include immunocompromised as well as immunocompetent patients having several associated risk factors.
We report three cases in which K. ohmeri was isolated from blood using Bact T/ALERT. Identification was carried out by MALDI-TOF MS (Vitek-MS, BioMérieux, Marcy-l'Etoile, France) in addition to color characteristics on chromogenic media. The patients had diminished immune response on account of a multitude of comorbidities.
K. ohmeri can be misidentified as Candida tropicalis, Candida albicans, or Candida hemolounii by conventional methods; correct and timely identification can be achieved by MALDI-TOF MS. Antifungal susceptibility breakpoints for K. ohmeri are currently not defined. An Echinocandin was added to the treatment regimen of all three of the cases.
Identification of K. ohmeri using conventional methods is difficult and unusual yeasts should be carefully observed, especially upon prolonged incubation.
Ohmeromyces kodamaea 是一种罕见的已被确认的病原体，先前从环境源中分离得到。受这种酵母影响的患者通常包括免疫功能低下以及有多种相关危险因素的免疫功能正常的患者。
我们报告了三例使用 Bact T/ALERT 从血液中分离出 O. kodamaea 的病例。通过 MALDI-TOF MS（Vitek-MS，法国马里-莱泰尔的生物梅里埃）进行鉴定，此外还在显色培养基上进行颜色特征鉴定。患者由于多种合并症而免疫反应减弱。
传统方法可能将 O. kodamaea 错误鉴定为热带假丝酵母、白色假丝酵母或溶血假丝酵母；MALDI-TOF MS 可实现正确且及时的鉴定。目前尚未为 O. kodamaea 定义抗真菌药敏折点。所有三个病例的治疗方案中均添加了棘白菌素。
使用传统方法鉴定 O. kodamaea 较为困难，应仔细观察不常见的酵母，尤其是在长时间孵育时。
