Department of Research, IR Iran Medical Council, Genomic Research Center, National Center for Genomic Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Infect Dev Ctries. 2024 Apr 30;18(4):532-541. doi: 10.3855/jidc.17691.
This study assessed the incidence and severity of side effects associated with coronavirus disease 2019 (COVID-19) vaccination among healthcare workers registered with the Medical Council of the Islamic Republic of Iran.
A retrospective cohort study was conducted on the healthcare workers focusing on the side-effects of COVID-19 vaccines from March to June 2021. Data were collected using online questionnaires. Multivariable logistic regression was used to assess the association between side effects of the vaccines and demographic variables, comorbidities, vaccine type, and history of COVID-19.
Out of 42,018 people who were included, 55.85% reported at least one side effect after receiving the first vaccine dose. 4.59% of those with side effects sought diagnostic intervention or were referred to treatment centers. Multivariable logistic regression indicated that being a woman, higher education, having a history of COVID-19 infection, and having comorbidities increased the risk of side effects. The AstraZeneca vaccine significantly increased the risk of side effects compared to the Sputnik vaccine, while the Sinopharm vaccine decreased this risk. The risk of developing a side effect decreased with age. The risk of moderate and severe side effects was significantly associated with gender, younger age, comorbidities, and a history of COVID-19 infection. Moderate and severe side effects were less reported by those who received the Sinopharm vaccine.
Clinical complications after COVID-19 vaccination, directly or indirectly caused by the vaccines, are common. However, the benefits of COVID-19 vaccines greatly outweigh the risk of reversible side effects, especially among the high-risk population.
本研究评估了在伊朗伊斯兰共和国医学委员会注册的医护人员中与 2019 年冠状病毒病（COVID-19）疫苗接种相关的副作用的发生率和严重程度。
这是一项回顾性队列研究，研究对象为 2021 年 3 月至 6 月期间 COVID-19 疫苗副作用的医护人员。数据通过在线问卷收集。多变量逻辑回归用于评估疫苗副作用与人口统计学变量、合并症、疫苗类型和 COVID-19 病史之间的关联。
在纳入的 42018 人中，55.85%的人在接种第一剂疫苗后至少出现了一种副作用。有副作用的人中，4.59%寻求诊断干预或被转介到治疗中心。多变量逻辑回归表明，女性、较高的教育程度、有 COVID-19 感染史和合并症会增加副作用的风险。与 Sputnik 疫苗相比，AstraZeneca 疫苗显著增加了副作用的风险，而 Sinopharm 疫苗降低了这种风险。副作用的风险随年龄的增长而降低。中度和重度副作用的风险与性别、年龄较小、合并症和 COVID-19 感染史显著相关。接受 Sinopharm 疫苗的人报告中度和重度副作用的风险较低。
COVID-19 疫苗接种后的临床并发症，无论是直接还是间接由疫苗引起，都很常见。然而，COVID-19 疫苗的益处大大超过可逆副作用的风险，特别是在高危人群中。
