Department of Obstetrics and Gynecology, Womack Army Medical Center, 2817 Rock Merritt Avenue, Fort Liberty, NC 28310, USA.
Department of Research, Womack Army Medical Center, 2817 Rock Merritt Avenue, Fort Liberty, NC 28310, USA.
Eur J Obstet Gynecol Reprod Biol. 2024 Jul;298:49-52. doi: 10.1016/j.ejogrb.2024.03.016. Epub 2024 Mar 27.
Organophosphate pesticides such as malathion are the most widely used pesticides. Despite endocrine-disrupting effects, there is a paucity of information regarding chronic exposure to non-persistent organopesticides such as malathion. The purpose of this study is to describe the exposure burden among U.S. residents as well as possible impacts on fertility.
Population-based data collected by the National Health and Nutrition Examination Survey (NHANES) between 2015 and 2016 were used to perform a retrospective analysis on urinary concentrations of malathion diacid. Samples were assessed from 1703 adult participants, statistically weighted to represent over 231 million individuals. General linear models were used to examine associations between exposure and reproductive health measures among pre-menopausal women.
Detectable concentrations of malathion diacid were identified in 16.1 % (n = 254) of samples. Concentrations were higher among women who reported seeing a physician due to difficulties becoming pregnant (P < 0.001; r = 0.12) as well as among women who reported trying for at least a year to become pregnant (P < 0.001; r = 0.06).
Exposure to malathion is associated with a history of reproductive health challenges among women.
马拉硫磷等有机磷农药是使用最广泛的农药。尽管有机磷农药具有内分泌干扰作用，但对于马拉硫磷等非持久性有机农药的慢性暴露，相关信息仍然匮乏。本研究旨在描述美国居民的暴露负担以及其对生育能力的可能影响。
本研究采用 2015 年至 2016 年期间通过国家健康和营养检查调查（NHANES）收集的基于人群的数据进行回顾性分析，检测马拉硫磷二酸在尿液中的浓度。对来自 1703 名成年参与者的样本进行了评估，这些样本经过统计学加权，以代表超过 2.31 亿人。采用一般线性模型检验暴露与绝经前妇女生殖健康指标之间的关联。
在 16.1%（n=254）的样本中检测到马拉硫磷二酸的可检测浓度。与因受孕困难而看医生的女性（P<0.001；r=0.12）以及报告至少尝试怀孕一年的女性（P<0.001；r=0.06）相比，报告该物质的浓度更高。
马拉硫磷的暴露与女性生殖健康挑战的病史有关。
