Alkireidmi Mohammed Ahmed, Mehanna Mohamed Gamil, Baig Mirza Rafi, Al-Abbasi Fahad Ahmed, Almalki Naif Abdullah Raddah, Asar Turky Omar, Firoz Ahmad, Kumar Vikas, Anwar Firoz
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Curr Med Chem. 2025;32(25):5350-5365. doi: 10.2174/0109298673343390241214050107.
Infertility was often considered a female issue, but male infertility emerged significantly after the COVID-19 pandemic. Hence, assessments are crucial for planning policies on health care and family planning and reasons thereof post vaccinations.
The present study was a case-control, dual-centers, prospective study with normal sperm parameters. Semen samples collected by masturbation for idiopathic reasons were conducted at King Abdulaziz University with 133 samples, followed by molecular modeling via interaction between IZUMO1, Alpha2A adrenergic receptor, and Fibroblast growth factor receptor 2 protein with IgA antibody produced post vaccination/infection.
The infertile males under 30 (21%), 31-40 (50%), 41-50 (24%) and over 50 (5%), with altered sperm motility grades are A (8.45%), B (11.1%), C (15.8%), and D (59.8%) were reported. Liquefaction times range from 36 to 30 minutes by age, with abnormal sperm percentages between 43.85% and 46.33%. Protein molecular interaction between IZUMO1, Alpha2A adrenergic receptor, and Fibroblast growth factor receptor 2 protein with IgA antibody shows cumulative length of 25.354 Å, 39.049 Å, and 41.999 Å, respectively, with significant interaction between atoms chain, amino acid, marked variation in bond length.
Male infertility peaks at 31-40 years, with lowering in men aged 41-50 years, IgA antibody reduced sperm motility, causing immunogenic infertility exacerbated post-COVID-19 vaccination or infection. Interaction of IgA and various receptors produced stable interactive molecules of IgA and proteins on sperm, affecting motility, aliquefication, and abnormal sperm percentage disturbing the normal dynamics of sperm cells opening a new dimension of infertility among males.
不孕症曾常被视为女性问题，但在新冠疫情后男性不育问题显著出现。因此，评估对于制定医疗保健和计划生育政策及其接种疫苗后的原因至关重要。
本研究为病例对照、双中心、前瞻性研究，纳入精子参数正常者。在阿卜杜勒阿齐兹国王大学，因特发性原因通过手淫收集了133份精液样本，随后通过IZUMO1、α2A肾上腺素能受体和成纤维细胞生长因子受体2蛋白与接种疫苗/感染后产生的IgA抗体之间的相互作用进行分子建模。
报告了30岁以下（21%）、31 - 40岁（50%）、41 - 50岁（24%）和50岁以上（5%）的不育男性，其精子活力等级改变的情况为：A级（8.45%）、B级（11.1%）、C级（15.8%）和D级（59.8%）。液化时间按年龄范围从36分钟到30分钟，异常精子百分比在43.85%至46.33%之间。IZUMO1、α2A肾上腺素能受体和成纤维细胞生长因子受体2蛋白与IgA抗体之间的蛋白质分子相互作用显示，累积长度分别为25.354 Å、39.049 Å和41.999 Å，原子链、氨基酸之间存在显著相互作用，键长有明显变化。
男性不育在31 - 40岁达到峰值，41 - 50岁男性有所下降，IgA抗体降低精子活力，导致新冠疫苗接种或感染后免疫性不育加剧。IgA与各种受体的相互作用产生了精子上IgA和蛋白质的稳定相互作用分子，影响活力、液化和异常精子百分比，扰乱了精子细胞的正常动态，开启了男性不育的新维度。
