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单克隆抗体的发展推动了马的免疫学研究。

Monoclonal antibody development advances immunological research in horses.

机构信息

Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

出版信息

Vet Immunol Immunopathol. 2024 Jun;272:110771. doi: 10.1016/j.vetimm.2024.110771. Epub 2024 May 6.

Abstract

Host immune analyses require specific reagents to identify cellular and soluble components of the immune system. These immune reagents are often species-specific. For horses, various immunological tools have been developed and tested by different initiatives during the past decades. This article summarizes the development of well characterized monoclonal antibodies (mAbs) for equine immune cells, immunoglobulin isotypes, cytokines, and chemokines.

摘要

宿主免疫分析需要特定的试剂来鉴定免疫系统的细胞和可溶性成分。这些免疫试剂通常具有物种特异性。在过去几十年中,不同的研究团队已经开发并测试了各种针对马的免疫工具。本文总结了用于鉴定马的免疫细胞、免疫球蛋白同种型、细胞因子和趋化因子的经过充分鉴定的单克隆抗体 (mAbs) 的发展。

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