Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2024 Mar;176(5):612-616. doi: 10.1007/s10517-024-06078-z. Epub 2024 May 11.
We experimentally demonstrated that chronic social stress during the development of a depression-like state enhances lung metastasis and modifies the expression of many carcinogenesis- and apoptosis-related genes in the hypothalamus of mice, including genes involved in lung cancer pathogenesis in humans. Analysis of the expression of genes encoding the major clinical markers of lung cancer in the hypothalamus of mice with depression-like behavior revealed increased expression of the Eno2 gene encoding neuron-specific enolase, a blood marker of lung cancer progression in humans. It was shown that the expression of this gene in the hypothalamus correlated with the expression of many carcinogenesis- and apoptosis-related genes. The discovered phenomenon may have a fundamental significance and requires further studies.
我们通过实验证明，在抑郁样状态发展过程中慢性社会压力会增强肺部转移，并改变小鼠下丘脑中许多与致癌和细胞凋亡相关的基因的表达，包括与人肺癌发病机制相关的基因。对具有抑郁样行为的小鼠下丘脑中编码肺癌主要临床标志物的基因表达分析显示，编码神经元特异性烯醇化酶的 Eno2 基因表达增加，而神经元特异性烯醇化酶是人类肺癌进展的血液标志物。结果表明，该基因在下丘脑中的表达与许多与致癌和细胞凋亡相关的基因的表达相关。这一发现可能具有重要意义，需要进一步研究。
