Department of Radiology, Kurume University Hospital, Asahimachi 67, Kurume, Japan.
Department of Radiological Technology, Faculty of Medical Technology, Teikyo University, 2-11-1, Kaga, Itabashi-Ku, Tokyo, Japan.
Radiol Phys Technol. 2024 Sep;17(3):637-644. doi: 10.1007/s12194-024-00811-z. Epub 2024 May 10.
Non-alcoholic fatty liver disease (NAFLD) and its advanced stage, non-alcoholic steatohepatitis (NASH), have become increasingly prevalent owing to the rise in metabolic syndromes. Accurate assessment of hepatic fat deposition and inflammation is crucial for diagnosing and managing NAFLD/NASH. We investigated the influence of Gd-EOB-DTPA, (EOB) on proton-density fat fraction (PDFF) measurements using chemical shift-encoded magnetic resonance imaging (CSE-MRI) at 3-T. In total, 431 patients who underwent EOB contrast-enhanced MRI were included. PDFF measurements were obtained from pre- and post-contrast CSE-MRI. Linear regression and Bland-Altman analyses were performed to assess the correlation and agreement between pre- and post-EOB PDFF measurements. Relative enhancement (RE) of the liver was calculated as an EOB uptake index. There was a significant decrease in PDFF following EOB administration compared with the pre-contrast values (P < 0.0001), which was observed across all PDFF ranges (< 10% and ≥ 10%). Linear regression analysis revealed high correlation between pre- and post-EOB PDFF measurements. Bland-Altman analysis indicated a small bias between pre- and post-EOB PDFF values. Subgroup analysis based on RE showed a significant difference in ΔPDFF between patients with high RE (> 120%) and those with lower RE levels. EOB administration resulted in a slight decrease in PDFF measurements obtained using CSE-MRI at 3-T. We were able to generalize and clarify that the PDFF of the liver on 3D CSE-MRI at 3-T was slightly decreased after EOB administration as we used a larger group of patients compared to previous studies.
非酒精性脂肪性肝病（NAFLD）及其进展期非酒精性脂肪性肝炎（NASH）由于代谢综合征的增加而变得越来越普遍。准确评估肝脂肪沉积和炎症对于诊断和管理 NAFLD/NASH 至关重要。我们研究了钆-EOB-DTPA（EOB）在 3-T 化学位移编码磁共振成像（CSE-MRI）上对质子密度脂肪分数（PDFF）测量的影响。共纳入 431 例接受 EOB 对比增强 MRI 的患者。在 CSE-MRI 前后进行 PDFF 测量。采用线性回归和 Bland-Altman 分析评估 EOB 前后 PDFF 测量之间的相关性和一致性。计算肝的相对增强（RE）作为 EOB 摄取指数。与对比前值相比，EOB 给药后 PDFF 显著降低（P<0.0001），这在所有 PDFF 范围内均可见（<10%和≥10%）。线性回归分析显示 EOB 前后 PDFF 测量之间具有高度相关性。Bland-Altman 分析表明 EOB 前后 PDFF 值之间存在小偏差。基于 RE 的亚组分析显示，高 RE（>120%）患者和低 RE 水平患者之间的ΔPDFF 差异有统计学意义。EOB 给药后，3-T CSE-MRI 获得的 PDFF 测量值略有下降。我们能够概括并阐明，与之前的研究相比，我们使用了更大的患者群体，因此在 3-T 上进行 3D CSE-MRI 时，肝的 PDFF 在 EOB 给药后会略有降低。
